Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007

Jian Te Lee, Ting Yu Yen, Wei Liang Shih, Chun Yi Lu, Ding Ping Liu, Yi Chuan Huang, Luan Yin Chang, Li Min Huang, Tzou Yien Lin

Research output: Contribution to journalArticle

Abstract

Background During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017. Methods After informed consent was obtained, we enrolled preschool children, 6-15-year-old students, 16-50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody. Results Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10% (8/82) in infants, 4% (6/153) in 1-year-old children, 8% (7/83) in 2- year-old children, 8% (13/156) in 3-5-year-old children, 31% (38/122) in 6-11-year-old primary school students, 45% (54/121) in 12-15-year-old high school students and 75% (152/ 203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16-50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017. Conclusion EV71 seropositive rates were very low, at 4% to 10%, in preschool children and not high, at 31%, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.

Original languageEnglish
Article numbere0224110
JournalPLoS ONE
Volume14
Issue number10
DOIs
Publication statusPublished - Jan 1 2019

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Enterovirus
serological surveys
Taiwan
Students
Preschool Children
preschool children
Vaccines
elementary students
risk factors
Blood
Herpangina
Siblings
seroprevalence
Hand, Foot and Mouth Disease
Enterovirus Infections
hand, foot and mouth disease
Antibodies
vaccines
high school students
Informed Consent

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007. / Lee, Jian Te; Yen, Ting Yu; Shih, Wei Liang; Lu, Chun Yi; Liu, Ding Ping; Huang, Yi Chuan; Chang, Luan Yin; Huang, Li Min; Lin, Tzou Yien.

In: PLoS ONE, Vol. 14, No. 10, e0224110, 01.01.2019.

Research output: Contribution to journalArticle

Lee, JT, Yen, TY, Shih, WL, Lu, CY, Liu, DP, Huang, YC, Chang, LY, Huang, LM & Lin, TY 2019, 'Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007', PLoS ONE, vol. 14, no. 10, e0224110. https://doi.org/10.1371/journal.pone.0224110
Lee, Jian Te ; Yen, Ting Yu ; Shih, Wei Liang ; Lu, Chun Yi ; Liu, Ding Ping ; Huang, Yi Chuan ; Chang, Luan Yin ; Huang, Li Min ; Lin, Tzou Yien. / Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007. In: PLoS ONE. 2019 ; Vol. 14, No. 10.
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abstract = "Background During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017. Methods After informed consent was obtained, we enrolled preschool children, 6-15-year-old students, 16-50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody. Results Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10{\%} (8/82) in infants, 4{\%} (6/153) in 1-year-old children, 8{\%} (7/83) in 2- year-old children, 8{\%} (13/156) in 3-5-year-old children, 31{\%} (38/122) in 6-11-year-old primary school students, 45{\%} (54/121) in 12-15-year-old high school students and 75{\%} (152/ 203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16-50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017. Conclusion EV71 seropositive rates were very low, at 4{\%} to 10{\%}, in preschool children and not high, at 31{\%}, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.",
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AU - Lee, Jian Te

AU - Yen, Ting Yu

AU - Shih, Wei Liang

AU - Lu, Chun Yi

AU - Liu, Ding Ping

AU - Huang, Yi Chuan

AU - Chang, Luan Yin

AU - Huang, Li Min

AU - Lin, Tzou Yien

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Y1 - 2019/1/1

N2 - Background During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017. Methods After informed consent was obtained, we enrolled preschool children, 6-15-year-old students, 16-50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody. Results Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10% (8/82) in infants, 4% (6/153) in 1-year-old children, 8% (7/83) in 2- year-old children, 8% (13/156) in 3-5-year-old children, 31% (38/122) in 6-11-year-old primary school students, 45% (54/121) in 12-15-year-old high school students and 75% (152/ 203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16-50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017. Conclusion EV71 seropositive rates were very low, at 4% to 10%, in preschool children and not high, at 31%, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.

AB - Background During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017. Methods After informed consent was obtained, we enrolled preschool children, 6-15-year-old students, 16-50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody. Results Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10% (8/82) in infants, 4% (6/153) in 1-year-old children, 8% (7/83) in 2- year-old children, 8% (13/156) in 3-5-year-old children, 31% (38/122) in 6-11-year-old primary school students, 45% (54/121) in 12-15-year-old high school students and 75% (152/ 203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16-50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017. Conclusion EV71 seropositive rates were very low, at 4% to 10%, in preschool children and not high, at 31%, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.

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