Enterovirus 71 outbreaks, Taiwan: Occurrence and recognition

Tzou Yien Lin, Shiing Jer Twu, Mei Shang Ho, Luan Yin Chang, Chin Yun Lee

Research output: Contribution to journalShort survey

161 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) caused a large outbreak in Taiwan in 1998 with 78 deaths, and smaller outbreaks recurred in 2000 and 2001. The outbreak was recognized because of a large number of hand, foot, and mouth disease cases and the rapid deaths of children with the disease. Virologic and pathologic studies indicated that EV71 was the most important agent related to severe and fatal cases and that a neurogenic inflammatory response was involved in the pathogenesis of cardiopulmonary collapse resulting from fulminant EV71 infection. Seroepidemiologic study suggested that EV71 had circulated for at least 16 years and that the accumulation of susceptible hosts might have triggered the 1998 outbreak. However, a change in EV71 neurovirulence and host genetic susceptibility may also have affected the clinical outcome. The Taiwan outbreak shows that worldwide attention should be paid to such outbreaks, new antiviral drugs should be developed, and that vaccination of children under 5 years of age may be warranted.

Original languageEnglish
Pages (from-to)291-293
Number of pages3
JournalEmerging Infectious Diseases
Volume9
Issue number3
Publication statusPublished - Mar 1 2003
Externally publishedYes

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Enterovirus
Taiwan
Disease Outbreaks
Hand, Foot and Mouth Disease
Enterovirus Infections
Seroepidemiologic Studies
Genetic Predisposition to Disease
Antiviral Agents
Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Lin, T. Y., Twu, S. J., Ho, M. S., Chang, L. Y., & Lee, C. Y. (2003). Enterovirus 71 outbreaks, Taiwan: Occurrence and recognition. Emerging Infectious Diseases, 9(3), 291-293.

Enterovirus 71 outbreaks, Taiwan : Occurrence and recognition. / Lin, Tzou Yien; Twu, Shiing Jer; Ho, Mei Shang; Chang, Luan Yin; Lee, Chin Yun.

In: Emerging Infectious Diseases, Vol. 9, No. 3, 01.03.2003, p. 291-293.

Research output: Contribution to journalShort survey

Lin, TY, Twu, SJ, Ho, MS, Chang, LY & Lee, CY 2003, 'Enterovirus 71 outbreaks, Taiwan: Occurrence and recognition', Emerging Infectious Diseases, vol. 9, no. 3, pp. 291-293.
Lin TY, Twu SJ, Ho MS, Chang LY, Lee CY. Enterovirus 71 outbreaks, Taiwan: Occurrence and recognition. Emerging Infectious Diseases. 2003 Mar 1;9(3):291-293.
Lin, Tzou Yien ; Twu, Shiing Jer ; Ho, Mei Shang ; Chang, Luan Yin ; Lee, Chin Yun. / Enterovirus 71 outbreaks, Taiwan : Occurrence and recognition. In: Emerging Infectious Diseases. 2003 ; Vol. 9, No. 3. pp. 291-293.
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