Enhancing the sensitivity of portable biosensors based on self-powered ion concentration polarization and electrical kinetic trapping

Yu Jui Fan, Ming Zheng Huang, Yu Cheng Hsiao, Yu Wen Huang, Chih Zong Deng, Cheng Yeh, Rashaad A. Husain, Zong Hong Lin

Research output: Contribution to journalArticle

Abstract

Preconcentration of biomolecules for detection on microfluidic platforms based on electrical kinetic trapping (EKT) through ion concentration polarization (ICP) has been well developed in the past decade. Biomolecules can be entrapped due to the equilibrium of forces between electro-osmosis and ICP when applying a voltage to the system. However, the voltage required to trigger ICP phenomena in microfluidics is normally 30–80 V DC, which is a barrier to ICP-based nanofluidic preconcentrators becoming portable point-of-care devices. In this study, we developed a triboelectric nanogenerator (TENG)-driven nanofluidic preconcentrating device that is able to trigger ICP and subsequently cause the EKT of the biomolecules without using a conventional electrical power source. The EKT and electrical characteristics of the TENG-based nanofluidic preconcentrator were studied. Furthermore, the TENG-based nanofluidic preconcentrator was integrated with a smartphone-enabled bead immunoassay to become a portable and highly sensitive biosensor. The preconcentration and trapping processes were developed, and the bead-immunoassay on a smartphone with/without preconcentration was demonstrated to determine the preconcentration factors.

Original languageEnglish
Article number104407
JournalNano Energy
Volume69
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Electrical kinetic trapping
  • Ion concentration polarization
  • Nanofluidic preconcentration
  • Self-powered sensor
  • Triboelectric nanogenerator

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Materials Science(all)
  • Electrical and Electronic Engineering

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