Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Vijendra K. Singh, Sy Jye Christine Leu

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalNeuroscience Letters
Volume120
Issue number2
DOIs
Publication statusPublished - Dec 11 1990
Externally publishedYes

Keywords

  • Corticotropin-releasing factor
  • Interleukin production
  • Neuroimmunomodulation

ASJC Scopus subject areas

  • Neuroscience(all)

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