Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

Vijendra K. Singh, Sy Jye Christine Leu

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalNeuroscience Letters
Volume120
Issue number2
DOIs
Publication statusPublished - Dec 11 1990
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Interleukin-1
Adrenocorticotropic Hormone
Interleukin-2
Neurotransmitter Agents
Phytohemagglutinins
Lipopolysaccharides
Immune System
Healthy Volunteers
Molecular Weight

Keywords

  • Corticotropin-releasing factor
  • Interleukin production
  • Neuroimmunomodulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2. / Singh, Vijendra K.; Leu, Sy Jye Christine.

In: Neuroscience Letters, Vol. 120, No. 2, 11.12.1990, p. 151-154.

Research output: Contribution to journalArticle

@article{d7243bcdafc04b82beb68a47df001f68,
title = "Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2",
abstract = "Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.",
keywords = "Corticotropin-releasing factor, Interleukin production, Neuroimmunomodulation",
author = "Singh, {Vijendra K.} and Leu, {Sy Jye Christine}",
year = "1990",
month = "12",
day = "11",
doi = "10.1016/0304-3940(90)90025-5",
language = "English",
volume = "120",
pages = "151--154",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2

AU - Singh, Vijendra K.

AU - Leu, Sy Jye Christine

PY - 1990/12/11

Y1 - 1990/12/11

N2 - Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

AB - Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

KW - Corticotropin-releasing factor

KW - Interleukin production

KW - Neuroimmunomodulation

UR - http://www.scopus.com/inward/record.url?scp=0025705776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025705776&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(90)90025-5

DO - 10.1016/0304-3940(90)90025-5

M3 - Article

C2 - 2293102

AN - SCOPUS:0025705776

VL - 120

SP - 151

EP - 154

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -