Enhancement of hemocompatibility on titanium implant with titanium-doped diamond-like carbon film evaluated by cellular reactions using bone marrow cell cultures in vitro

Wen Chung Feng, Chau Hsiang Wang, Hsin Chung Cheng, Shi Yung Chiou, Chin Sung Chen, Keng Liang Ou

Research output: Contribution to journalArticle

12 Citations (Scopus)


The purpose of this study is to evaluate a new method to deposit a-C:H film with the biological acceptance of titanium as a protective coating material in biomedical applications. For this purpose, various amounts of titanium were incorporated into a-C:H films by a combined radio frequency and magnetron sputtering system. In order to realize the properties of a-C:H films with and without Ti, the specimens were evaluated by material analyses and cell culture. The Ti and TiC were embedded in and connected to an amorphous a-C:H matrix. The a-C:H/Ti film has better capability of osteoblast differentiation than Ti and a-C:H, revealing that the biocompatibility of a-C:H containing Ti is obviously better than a-C:H. It is believed that the Ti plays an important role in enhancing the film's adhesion and biocompatibility. Furthermore, it also revealed the issue of hemocompatibility and that blood/ a-C:H/Ti interactions as a function of surface roughness can affect the red blood cell (RBC) distributions in early tissue healing. The different surface roughness can result in various blood cell responses as investigated by RBC distribution and platelet aggregation.

Original languageEnglish
Pages (from-to)1559-1565
Number of pages7
JournalJournal of Vacuum Science and Technology B:Nanotechnology and Microelectronics
Issue number3
Publication statusPublished - 2009


ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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