Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3', 5'-monophosphate 1

Robert C. Gallo; Jacqueline Whang-Peng

doi:10.1093/jnci/47.1.91

Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3', 5'-monophosphate 1

Robert C. Gallo, Jacqueline Whang-Peng

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Dibutyryl adenosine cyclic 3', 5'-monophosphate (10'7-10-6 M) augmented the response (transformation, DNA synthesis, and mitosis)of normal human lymphocytes to antigenic or mitogenic stimulation. Incontrast, the response of lymphocytes from patients with lymphocyticleukemia was not enhanced. Higher concentrations (10-6-10-5 M) wereinhibitory with both normal and leukemic lymphocytes.—J Nat CancerInst 47: 91-94, 1971.

Original language	English
Pages (from-to)	91-94
Number of pages	4
Journal	Journal of the National Cancer Institute
Volume	47
Issue number	1
DOIs	https://doi.org/10.1093/jnci/47.1.91
Publication status	Published - Jan 1 1971
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Dibutyryl adenosine cyclic 3', 5'-monophosphate (10'7-10-6 M) augmented the response (transformation, DNA synthesis, and mitosis)of normal human lymphocytes to antigenic or mitogenic stimulation. Incontrast, the response of lymphocytes from patients with lymphocyticleukemia was not enhanced. Higher concentrations (10-6-10-5 M) wereinhibitory with both normal and leukemic lymphocytes.—J Nat CancerInst 47: 91-94, 1971.",

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AB - Dibutyryl adenosine cyclic 3', 5'-monophosphate (10'7-10-6 M) augmented the response (transformation, DNA synthesis, and mitosis)of normal human lymphocytes to antigenic or mitogenic stimulation. Incontrast, the response of lymphocytes from patients with lymphocyticleukemia was not enhanced. Higher concentrations (10-6-10-5 M) wereinhibitory with both normal and leukemic lymphocytes.—J Nat CancerInst 47: 91-94, 1971.

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Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3', 5'-monophosphate 1

Abstract

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