Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3', 5'-monophosphate 1

Robert C. Gallo, Jacqueline Whang-Peng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dibutyryl adenosine cyclic 3', 5'-monophosphate (10'7-10-6 M) augmented the response (transformation, DNA synthesis, and mitosis)of normal human lymphocytes to antigenic or mitogenic stimulation. Incontrast, the response of lymphocytes from patients with lymphocyticleukemia was not enhanced. Higher concentrations (10-6-10-5 M) wereinhibitory with both normal and leukemic lymphocytes.—J Nat CancerInst 47: 91-94, 1971.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of the National Cancer Institute
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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