Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3', 5'-monophosphate 1

Robert C. Gallo, Jacqueline Whang-Peng

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8 Citations (Scopus)


Dibutyryl adenosine cyclic 3', 5'-monophosphate (10'7-10-6 M) augmented the response (transformation, DNA synthesis, and mitosis)of normal human lymphocytes to antigenic or mitogenic stimulation. Incontrast, the response of lymphocytes from patients with lymphocyticleukemia was not enhanced. Higher concentrations (10-6-10-5 M) wereinhibitory with both normal and leukemic lymphocytes.—J Nat CancerInst 47: 91-94, 1971.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of the National Cancer Institute
Issue number1
Publication statusPublished - Jan 1 1971
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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