Enhanced non-endocytotic uptake of mesoporous silica nanoparticles by shortening the peptide transporter arginine side Chain

Cheng Hsun Wu, Yi Ping Chen, Si Han Wu, Yann Hung, Chung Yuan Mou, Richard P. Cheng

Research output: Contribution to journalArticle

14 Citations (Scopus)


Mesoporous silica nanoparticles (MSNs) are multifunctional nanocarriers with potential biomedical applications. However, MSNs are frequently trapped in endosomes upon cellular uptake through endocytosis, requiring endosomal escape. Herein, enhanced nonendocytosis was observed for 300 nm MSNs by conjugating peptides with noncanonical arginine analogs.

Original languageEnglish
Pages (from-to)12244-12248
Number of pages5
JournalACS Applied Materials and Interfaces
Issue number23
Publication statusPublished - Dec 11 2013
Externally publishedYes



  • arginine analogs
  • cellular uptake
  • mesoporous materials
  • non-natural peptides
  • nonendocytosis

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

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