Enhanced detectability in proteome studies

Supawadee Sriyam, Supachok Sinchaikul, Payungsak Tantipaiboonwong, Ching Tzao, Suree Phutrakul, Shui Tein Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The discovery of candidate biomarkers from biological materials coupled with the development of detection methods holds both incredible clinical potential as well as significant challenges. However, the proteomic techniques still provide the low dynamic range of protein detection at lower abundances. This review describes the current development of potential methods to enhance the detection and quantification in proteome studies. It also includes the bioinformatics tools that are helpfully used for data mining of protein ontology. Therefore, we believe that this review provided many proteomic approaches, which would be very potent and useful for proteome studies and for further diagnostic and therapeutic applications.

Original languageEnglish
Pages (from-to)91-104
Number of pages14
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume849
Issue number1-2
DOIs
Publication statusPublished - Apr 15 2007
Externally publishedYes

Keywords

  • Detection
  • Limitation
  • Proteome
  • Proteomic analysis
  • Sample preparation

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Sriyam, S., Sinchaikul, S., Tantipaiboonwong, P., Tzao, C., Phutrakul, S., & Chen, S. T. (2007). Enhanced detectability in proteome studies. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 849(1-2), 91-104. https://doi.org/10.1016/j.jchromb.2006.10.065