Endothelial progenitor cell dysfunction in cardiovascular diseases: Role of reactive oxygen species and inflammation

Chih Pei Lin, Feng Yen Lin, Po Hsun Huang, Yuh Lien Chen, Wen Chi Chen, Huey Yi Chen, Yu Chuen Huang, Wen Ling Liao, Huey Chun Huang, Po Len Liu, Yung Hsiang Chen

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Endothelial progenitor cells (EPCs) move towards injured endothelium or inflamed tissues and incorporate into foci of neovascularisation, thereby improving blood flow and tissue repair. Patients with cardiovascular diseases have been shown to exhibit reduced EPC number and function. It has become increasingly apparent that these changes may be effected in response to enhanced oxidative stress, possibly as a result of systemic and localised inflammatory responses. The interplay between inflammation and oxidative stress affects the initiation, progression, and complications of cardiovascular diseases. Recent studies suggest that inflammation and oxidative stress modulate EPC bioactivity. Clinical medications with anti-inflammatory and antioxidant properties, such as statins, thiazolidinediones, angiotensin II receptor 1 blockers, and angiotensin-converting enzyme inhibitors, are currently administered to patients with cardiovascular diseases. These medications appear to exert beneficial effects on EPC biology. This review focuses on EPC biology and explores the links between oxidative stress, inflammation, and development of cardiovascular diseases.

Original languageEnglish
Article number845037
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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Endothelial cells
Oxidative stress
Reactive Oxygen Species
Cardiovascular Diseases
Inflammation
Oxidative Stress
Cytology
Cell Biology
Tissue
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Thiazolidinediones
Angiotensin Receptors
Angiotensin Receptor Antagonists
Bioactivity
Angiotensin-Converting Enzyme Inhibitors
Endothelium
Repair
Blood
Anti-Inflammatory Agents
Cell Count

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Endothelial progenitor cell dysfunction in cardiovascular diseases : Role of reactive oxygen species and inflammation. / Lin, Chih Pei; Lin, Feng Yen; Huang, Po Hsun; Chen, Yuh Lien; Chen, Wen Chi; Chen, Huey Yi; Huang, Yu Chuen; Liao, Wen Ling; Huang, Huey Chun; Liu, Po Len; Chen, Yung Hsiang.

In: BioMed Research International, Vol. 2013, 845037, 2013.

Research output: Contribution to journalArticle

Lin, CP, Lin, FY, Huang, PH, Chen, YL, Chen, WC, Chen, HY, Huang, YC, Liao, WL, Huang, HC, Liu, PL & Chen, YH 2013, 'Endothelial progenitor cell dysfunction in cardiovascular diseases: Role of reactive oxygen species and inflammation', BioMed Research International, vol. 2013, 845037. https://doi.org/10.1155/2013/845037
Lin, Chih Pei ; Lin, Feng Yen ; Huang, Po Hsun ; Chen, Yuh Lien ; Chen, Wen Chi ; Chen, Huey Yi ; Huang, Yu Chuen ; Liao, Wen Ling ; Huang, Huey Chun ; Liu, Po Len ; Chen, Yung Hsiang. / Endothelial progenitor cell dysfunction in cardiovascular diseases : Role of reactive oxygen species and inflammation. In: BioMed Research International. 2013 ; Vol. 2013.
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