Endoscopic management of dieulafoy lesions in acute nonvariceal upper gastrointestinal bleeding

Chi Liang Cheng, Nai Jen Liu, Ching Song Lee, Pang Chi Chen, Yu Pin Ho, Jui-Hsiang Tang, Chun Yang, Kai Feng Sung, Cheng Hui Lin, Cheng Tang Chiu

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Dieulafoy lesion is an unusual but important cause of upper gastrointestinal bleeding. The study retrospectively reviewed 29 patients (2.1%) with Dieulafoy lesions of 1393 acute nonvariceal upper gastrointestinal bleeding episodes from October 1999 to May 2001. Nineteen patients (66%) were male and the median age was 62 years (range, 19 to 86 years). Two patients underwent emergent surgery after endoscopic diagnosis. The other patients were allocated to four therapeutic endoscopic groups: group I, epinephrine injection (11 patients); group II, epinephrine injection plus heater probe coagulation (10 patients); group III, histoacryl injection (4 patients); and group IV, hemoclipping (2 patients). Initial treatment failure ocurred in three patients (all in group I) and they received surgery, hemoclipping, or band ligation as salvage therapy, respectively. Among those who achieved initial hemostasis, recurrent bleeding developed in two patients (all in group I) and was successfully controlled by endoscopic injection plus thermal therapy. No complication was noted after endoscopic treatment. Group II had a significantly higher successful hemostasis rate than group I (100 vs 54%; P = 0.02). One patient in the therapeutic endoscopy groups died during admission, for a mortality rate of 3.7%. Patients were followed up from 6 to 36 months and no further bleeding was noted. The results suggest that epinephrine injection plus heater probe coagulation was significantly superior to epinephrine injection alone in achieving hemostasis. Histoacryl injection, hemoclipping, and endoscopic band ligation were safe and effective alternate therapies.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalDigestive Diseases and Sciences
Volume49
Issue number7-8
DOIs
Publication statusPublished - Aug 1 2004
Externally publishedYes

Fingerprint

Hemorrhage
Injections
Epinephrine
Hemostasis
Enbucrilate
Ligation
Therapeutics
Salvage Therapy
Treatment Failure
Endoscopy
Hot Temperature
Mortality

Keywords

  • Dieulafoy lesion
  • nonvariceal bleeding
  • therapeutic endoscopy
  • upper gastrointestinal bleeding

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Endoscopic management of dieulafoy lesions in acute nonvariceal upper gastrointestinal bleeding. / Cheng, Chi Liang; Liu, Nai Jen; Lee, Ching Song; Chen, Pang Chi; Ho, Yu Pin; Tang, Jui-Hsiang; Yang, Chun; Sung, Kai Feng; Lin, Cheng Hui; Chiu, Cheng Tang.

In: Digestive Diseases and Sciences, Vol. 49, No. 7-8, 01.08.2004, p. 1139-1144.

Research output: Contribution to journalReview article

Cheng, CL, Liu, NJ, Lee, CS, Chen, PC, Ho, YP, Tang, J-H, Yang, C, Sung, KF, Lin, CH & Chiu, CT 2004, 'Endoscopic management of dieulafoy lesions in acute nonvariceal upper gastrointestinal bleeding', Digestive Diseases and Sciences, vol. 49, no. 7-8, pp. 1139-1144. https://doi.org/10.1023/B:DDAS.0000037801.53304.5c
Cheng, Chi Liang ; Liu, Nai Jen ; Lee, Ching Song ; Chen, Pang Chi ; Ho, Yu Pin ; Tang, Jui-Hsiang ; Yang, Chun ; Sung, Kai Feng ; Lin, Cheng Hui ; Chiu, Cheng Tang. / Endoscopic management of dieulafoy lesions in acute nonvariceal upper gastrointestinal bleeding. In: Digestive Diseases and Sciences. 2004 ; Vol. 49, No. 7-8. pp. 1139-1144.
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AU - Ho, Yu Pin

AU - Tang, Jui-Hsiang

AU - Yang, Chun

AU - Sung, Kai Feng

AU - Lin, Cheng Hui

AU - Chiu, Cheng Tang

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N2 - Dieulafoy lesion is an unusual but important cause of upper gastrointestinal bleeding. The study retrospectively reviewed 29 patients (2.1%) with Dieulafoy lesions of 1393 acute nonvariceal upper gastrointestinal bleeding episodes from October 1999 to May 2001. Nineteen patients (66%) were male and the median age was 62 years (range, 19 to 86 years). Two patients underwent emergent surgery after endoscopic diagnosis. The other patients were allocated to four therapeutic endoscopic groups: group I, epinephrine injection (11 patients); group II, epinephrine injection plus heater probe coagulation (10 patients); group III, histoacryl injection (4 patients); and group IV, hemoclipping (2 patients). Initial treatment failure ocurred in three patients (all in group I) and they received surgery, hemoclipping, or band ligation as salvage therapy, respectively. Among those who achieved initial hemostasis, recurrent bleeding developed in two patients (all in group I) and was successfully controlled by endoscopic injection plus thermal therapy. No complication was noted after endoscopic treatment. Group II had a significantly higher successful hemostasis rate than group I (100 vs 54%; P = 0.02). One patient in the therapeutic endoscopy groups died during admission, for a mortality rate of 3.7%. Patients were followed up from 6 to 36 months and no further bleeding was noted. The results suggest that epinephrine injection plus heater probe coagulation was significantly superior to epinephrine injection alone in achieving hemostasis. Histoacryl injection, hemoclipping, and endoscopic band ligation were safe and effective alternate therapies.

AB - Dieulafoy lesion is an unusual but important cause of upper gastrointestinal bleeding. The study retrospectively reviewed 29 patients (2.1%) with Dieulafoy lesions of 1393 acute nonvariceal upper gastrointestinal bleeding episodes from October 1999 to May 2001. Nineteen patients (66%) were male and the median age was 62 years (range, 19 to 86 years). Two patients underwent emergent surgery after endoscopic diagnosis. The other patients were allocated to four therapeutic endoscopic groups: group I, epinephrine injection (11 patients); group II, epinephrine injection plus heater probe coagulation (10 patients); group III, histoacryl injection (4 patients); and group IV, hemoclipping (2 patients). Initial treatment failure ocurred in three patients (all in group I) and they received surgery, hemoclipping, or band ligation as salvage therapy, respectively. Among those who achieved initial hemostasis, recurrent bleeding developed in two patients (all in group I) and was successfully controlled by endoscopic injection plus thermal therapy. No complication was noted after endoscopic treatment. Group II had a significantly higher successful hemostasis rate than group I (100 vs 54%; P = 0.02). One patient in the therapeutic endoscopy groups died during admission, for a mortality rate of 3.7%. Patients were followed up from 6 to 36 months and no further bleeding was noted. The results suggest that epinephrine injection plus heater probe coagulation was significantly superior to epinephrine injection alone in achieving hemostasis. Histoacryl injection, hemoclipping, and endoscopic band ligation were safe and effective alternate therapies.

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