Endoscopic injection for the arrest of peptic ulcer hemorrhage

Final results of a prospective, randomized comparative trial

H. J. Lin, C. L. Perng, F. Y. Lee, C. Y. Chan, Z. C. Huang, S. D. Lee, C. H. Lee -

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

A prospective, randomized comparative study was performed to compare the hemostatic effect of endoscopic injection with normal saline, 3% NaCl solution, 50% glucose/water solution, and pure alcohol during a period of 2 years. Only patients with peptic ulcers and active bleeding or nonbleeding visible vessels were considered. Each group comprised 50 patients. The four groups were matched at random for age, sex, location of bleeders, stigmata of recent hemorrhage, shock, hemoglobin, and concomitant illness. No statistically significant difference was observed among patients injected with normal saline, 3% NaCl solution, 50% glucose/water solution, or pure alcohol in achieving initial hemostasis (82%, 90%, 86%, and 92%, respectively); rebleeding rates (7.3%, 24.4%, 14%, and 10.9%, respectively); ultimate hemostasis (78%, 68%, 78%, and 84%, respectively); number of emergency operations (5, 7, 4, and 3, respectively); and average number of days in the hospital (6.7, 6.1, 6.1, and 5.8, respectively). A tendency toward a lower blood transfusion requirement was observed in the pure alcohol group, but this tendency failed to achieve statistical significance. One patient had a perforated ulcer develop 5 days after injection of 3 ml 50% glucose/water. Otherwise, no major complication was observed. We suggest that endoscopic injection with any of the above solutions can be used as the first-line modality for the arrest of peptic ulcer hemorrhage.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalGastrointestinal Endoscopy
Volume39
Issue number1
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Peptic Ulcer Hemorrhage
Injections
Alcohols
Hemostasis
Glucose
Water
Hemorrhage
Christianity
Hemostatics
Peptic Ulcer
Blood Transfusion
Ulcer
Shock
Hemoglobins
Emergencies
Research Design

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lin, H. J., Perng, C. L., Lee, F. Y., Chan, C. Y., Huang, Z. C., Lee, S. D., & Lee -, C. H. (1993). Endoscopic injection for the arrest of peptic ulcer hemorrhage: Final results of a prospective, randomized comparative trial. Gastrointestinal Endoscopy, 39(1), 15-19.

Endoscopic injection for the arrest of peptic ulcer hemorrhage : Final results of a prospective, randomized comparative trial. / Lin, H. J.; Perng, C. L.; Lee, F. Y.; Chan, C. Y.; Huang, Z. C.; Lee, S. D.; Lee -, C. H.

In: Gastrointestinal Endoscopy, Vol. 39, No. 1, 1993, p. 15-19.

Research output: Contribution to journalArticle

Lin, H. J. ; Perng, C. L. ; Lee, F. Y. ; Chan, C. Y. ; Huang, Z. C. ; Lee, S. D. ; Lee -, C. H. / Endoscopic injection for the arrest of peptic ulcer hemorrhage : Final results of a prospective, randomized comparative trial. In: Gastrointestinal Endoscopy. 1993 ; Vol. 39, No. 1. pp. 15-19.
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