Endogenous formation of trans fatty acids: Health implications and potential dietary intervention

Wei Lun Hung, Lucy Sun Hwang, Fereidoon Shahidi, Min Hsiung Pan, Yu Wang, Chi Tang Ho

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Unsaturated fatty acids naturally occur as cis configuration and most dietary trans fatty acids (TFAs) originate from partially hydrogenated oils. High consumption of trans fats may cause several adverse effects on human health. However, the dietary source is not the only path by which TFAs are produced, but in vivo, they can also be formed endogenously via oxidative stress and by free radicals. Recent studies have demonstrated that thiyl radicals and nitrogen dioxide serve as the effective catalysts responsible for endogenous TFA formation through cis-trans isomerisation. Several in vivo studies have indicated that the occurrence of endogenous TFAs is closely linked with the development of some chronic diseases. Additionally, some vitamins and polyphenols exhibit inhibitory effects against the free radical-catalysed TFA formation in different in vitro experiments. Therefore, we postulate that dietary supplementation of antioxidants may serve as an effective strategy against endogenous TFA formation during pathogenesis of chronic diseases.

Original languageEnglish
Pages (from-to)14-24
Number of pages11
JournalJournal of Functional Foods
Volume25
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

Fingerprint

Trans Fatty Acids
trans fatty acids
Health
chronic diseases
Free Radicals
Chronic Disease
Nitrogen Dioxide
hydrogenated oils
isomerization
nitrogen dioxide
Polyphenols
Dietary Supplements
in vivo studies
Unsaturated Fatty Acids
catalysts
unsaturated fatty acids
Vitamins
human health
dietary supplements
vitamins

Keywords

  • Antioxidants
  • Endogenous trans fatty acids
  • Flavonoids
  • Nitrogen dioxide
  • Thiyl radicals
  • Vitamins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Endogenous formation of trans fatty acids : Health implications and potential dietary intervention. / Hung, Wei Lun; Sun Hwang, Lucy; Shahidi, Fereidoon; Pan, Min Hsiung; Wang, Yu; Ho, Chi Tang.

In: Journal of Functional Foods, Vol. 25, 01.08.2016, p. 14-24.

Research output: Contribution to journalReview article

Hung, Wei Lun ; Sun Hwang, Lucy ; Shahidi, Fereidoon ; Pan, Min Hsiung ; Wang, Yu ; Ho, Chi Tang. / Endogenous formation of trans fatty acids : Health implications and potential dietary intervention. In: Journal of Functional Foods. 2016 ; Vol. 25. pp. 14-24.
@article{dcf2f073c297445aaa6e33527cb85d09,
title = "Endogenous formation of trans fatty acids: Health implications and potential dietary intervention",
abstract = "Unsaturated fatty acids naturally occur as cis configuration and most dietary trans fatty acids (TFAs) originate from partially hydrogenated oils. High consumption of trans fats may cause several adverse effects on human health. However, the dietary source is not the only path by which TFAs are produced, but in vivo, they can also be formed endogenously via oxidative stress and by free radicals. Recent studies have demonstrated that thiyl radicals and nitrogen dioxide serve as the effective catalysts responsible for endogenous TFA formation through cis-trans isomerisation. Several in vivo studies have indicated that the occurrence of endogenous TFAs is closely linked with the development of some chronic diseases. Additionally, some vitamins and polyphenols exhibit inhibitory effects against the free radical-catalysed TFA formation in different in vitro experiments. Therefore, we postulate that dietary supplementation of antioxidants may serve as an effective strategy against endogenous TFA formation during pathogenesis of chronic diseases.",
keywords = "Antioxidants, Endogenous trans fatty acids, Flavonoids, Nitrogen dioxide, Thiyl radicals, Vitamins",
author = "Hung, {Wei Lun} and {Sun Hwang}, Lucy and Fereidoon Shahidi and Pan, {Min Hsiung} and Yu Wang and Ho, {Chi Tang}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.jff.2016.05.006",
language = "English",
volume = "25",
pages = "14--24",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Endogenous formation of trans fatty acids

T2 - Health implications and potential dietary intervention

AU - Hung, Wei Lun

AU - Sun Hwang, Lucy

AU - Shahidi, Fereidoon

AU - Pan, Min Hsiung

AU - Wang, Yu

AU - Ho, Chi Tang

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Unsaturated fatty acids naturally occur as cis configuration and most dietary trans fatty acids (TFAs) originate from partially hydrogenated oils. High consumption of trans fats may cause several adverse effects on human health. However, the dietary source is not the only path by which TFAs are produced, but in vivo, they can also be formed endogenously via oxidative stress and by free radicals. Recent studies have demonstrated that thiyl radicals and nitrogen dioxide serve as the effective catalysts responsible for endogenous TFA formation through cis-trans isomerisation. Several in vivo studies have indicated that the occurrence of endogenous TFAs is closely linked with the development of some chronic diseases. Additionally, some vitamins and polyphenols exhibit inhibitory effects against the free radical-catalysed TFA formation in different in vitro experiments. Therefore, we postulate that dietary supplementation of antioxidants may serve as an effective strategy against endogenous TFA formation during pathogenesis of chronic diseases.

AB - Unsaturated fatty acids naturally occur as cis configuration and most dietary trans fatty acids (TFAs) originate from partially hydrogenated oils. High consumption of trans fats may cause several adverse effects on human health. However, the dietary source is not the only path by which TFAs are produced, but in vivo, they can also be formed endogenously via oxidative stress and by free radicals. Recent studies have demonstrated that thiyl radicals and nitrogen dioxide serve as the effective catalysts responsible for endogenous TFA formation through cis-trans isomerisation. Several in vivo studies have indicated that the occurrence of endogenous TFAs is closely linked with the development of some chronic diseases. Additionally, some vitamins and polyphenols exhibit inhibitory effects against the free radical-catalysed TFA formation in different in vitro experiments. Therefore, we postulate that dietary supplementation of antioxidants may serve as an effective strategy against endogenous TFA formation during pathogenesis of chronic diseases.

KW - Antioxidants

KW - Endogenous trans fatty acids

KW - Flavonoids

KW - Nitrogen dioxide

KW - Thiyl radicals

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=84969749539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969749539&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2016.05.006

DO - 10.1016/j.jff.2016.05.006

M3 - Review article

AN - SCOPUS:84969749539

VL - 25

SP - 14

EP - 24

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -