Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function-A Magnetic Resonance Image Study

Lian Yu Lin, Mao Yuan M. Su, Van Truong Pham, Thi Thao Tran, Yung Hung Wang, Wen Yih I. Tseng, Men Tzung Lo, Jiunn Lee Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Left ventricular (LV) trabeculation has been studied in certain forms of cardiomyopathy. However, the changes of LV endocardial trabeculation during the remodeling process leading to heart failure (HF) are unclear. Seventy-four patients with systolic heart failure (SHF), 65 with heart failure with preserved ejection fraction (HFpEF) and 61 without HF were prospectively enrolled. All subjects received magnetic resonance imaging (MRI) study including cine, T1 and late gadolinium enhancement (LGE) images. Trabecular-papillary muscle (TPM) mass, fractal dimension (FD) and extracellular volume (ECV) were derived. The results showed that TPM mass index was higher in patients with SHF than that in patients with HFpEF and non-HF. The TPM mass-LV mass ratio (TPMm/LVM) was higher in SHF group than that in HFpEF and non-HF. FD was not different among groups. The presence of LGE was inversely associated with TPM mass index and TPMm/LVM while the ECV were positively associated with TPMm/LVM. The FD was positively associated with LV chamber size. In conclusion, TPM increases in patients with SHF and are probably related to myocardial cell hypertrophy and fibrotic repair during remodeling. The FD increases with the dilatation of LV chamber but remain unchanged with the deterioration of LV function.

Original languageEnglish
Article number20868
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Feb 15 2016
Externally publishedYes

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Papillary Muscles
Systolic Heart Failure
Fractals
Left Ventricular Function
Magnetic Resonance Spectroscopy
Heart Failure
Gadolinium
Image Enhancement
Cardiomyopathies
Hypertrophy
Dilatation
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • General

Cite this

Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function-A Magnetic Resonance Image Study. / Lin, Lian Yu; Su, Mao Yuan M.; Pham, Van Truong; Tran, Thi Thao; Wang, Yung Hung; Tseng, Wen Yih I.; Lo, Men Tzung; Lin, Jiunn Lee.

In: Scientific Reports, Vol. 6, 20868, 15.02.2016.

Research output: Contribution to journalArticle

Lin, Lian Yu ; Su, Mao Yuan M. ; Pham, Van Truong ; Tran, Thi Thao ; Wang, Yung Hung ; Tseng, Wen Yih I. ; Lo, Men Tzung ; Lin, Jiunn Lee. / Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function-A Magnetic Resonance Image Study. In: Scientific Reports. 2016 ; Vol. 6.
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