Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer

Pai Chien Chou, Shu Min Lin, Chun Yu Lo, Hao Cheng Chen, Chih Wei Wang, Chun Liang Chou, Chih Teng Yu, Horng Chyuan Lin, Chun Hua Wang, Han Pin Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods: We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results: 84% (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95% Confidence Interval [CI], 1.30-3.10), age (HR, 1.04; 95% CI, 1.03-1.06), and extensive stage (HR, 1.39; 95% CI, 1.06-1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95% CI, 0.25-0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion: Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.

Original languageEnglish
Article numbere47613
JournalPLoS One
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 4 2012
Externally publishedYes

Fingerprint

Small Cell Lung Carcinoma
lung neoplasms
mucosa
Mucous Membrane
Cells
Hazards
Survival
cells
Cytology
confidence interval
Chemotherapy
Biopsy
Confidence Intervals
Needles
Tomography
Bone
Fine Needle Biopsy
computed tomography
cell biology
drug therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer. / Chou, Pai Chien; Lin, Shu Min; Lo, Chun Yu; Chen, Hao Cheng; Wang, Chih Wei; Chou, Chun Liang; Yu, Chih Teng; Lin, Horng Chyuan; Wang, Chun Hua; Kuo, Han Pin.

In: PLoS One, Vol. 7, No. 10, e47613, 04.10.2012.

Research output: Contribution to journalArticle

Chou, Pai Chien ; Lin, Shu Min ; Lo, Chun Yu ; Chen, Hao Cheng ; Wang, Chih Wei ; Chou, Chun Liang ; Yu, Chih Teng ; Lin, Horng Chyuan ; Wang, Chun Hua ; Kuo, Han Pin. / Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer. In: PLoS One. 2012 ; Vol. 7, No. 10.
@article{fa4d3516de034d1ab331617723857fc9,
title = "Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer",
abstract = "Background: Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods: We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results: 84{\%} (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95{\%} Confidence Interval [CI], 1.30-3.10), age (HR, 1.04; 95{\%} CI, 1.03-1.06), and extensive stage (HR, 1.39; 95{\%} CI, 1.06-1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95{\%} CI, 0.25-0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion: Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.",
author = "Chou, {Pai Chien} and Lin, {Shu Min} and Lo, {Chun Yu} and Chen, {Hao Cheng} and Wang, {Chih Wei} and Chou, {Chun Liang} and Yu, {Chih Teng} and Lin, {Horng Chyuan} and Wang, {Chun Hua} and Kuo, {Han Pin}",
year = "2012",
month = "10",
day = "4",
doi = "10.1371/journal.pone.0047613",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - Endobronchial Mucosa Invasion Predicts Survival in Patients with Small Cell Lung Cancer

AU - Chou, Pai Chien

AU - Lin, Shu Min

AU - Lo, Chun Yu

AU - Chen, Hao Cheng

AU - Wang, Chih Wei

AU - Chou, Chun Liang

AU - Yu, Chih Teng

AU - Lin, Horng Chyuan

AU - Wang, Chun Hua

AU - Kuo, Han Pin

PY - 2012/10/4

Y1 - 2012/10/4

N2 - Background: Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods: We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results: 84% (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95% Confidence Interval [CI], 1.30-3.10), age (HR, 1.04; 95% CI, 1.03-1.06), and extensive stage (HR, 1.39; 95% CI, 1.06-1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95% CI, 0.25-0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion: Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.

AB - Background: Current staging system for small cell lung cancer (SCLC) categorizes patients into limited- or extensive-stage disease groups according to anatomical localizations. Even so, a wide-range of survival times has been observed among patients in the same staging system. This study aimed to identify whether endobronchial mucosa invasion is an independent predictor for poor survival in patients with SCLC, and to compare the survival time between patients with and without endobronchial mucosa invasion. Methods: We studied 432 consecutive patients with SCLC based on histological examination of biopsy specimens or on fine-needle aspiration cytology, and received computed tomography and bone scan for staging. All the enrolled patients were assessed for endobronchial mucosa invasion by bronchoscopic and histological examination. Survival days were compared between patients with or without endobronchial mucosa invasion and the predictors of decreased survival days were investigated. Results: 84% (364/432) of SCLC patients had endobronchial mucosal invasion by cancer cells at initial diagnosis. Endobronchial mucosal involvement (Hazard ratio [HR], 2.01; 95% Confidence Interval [CI], 1.30-3.10), age (HR, 1.04; 95% CI, 1.03-1.06), and extensive stage (HR, 1.39; 95% CI, 1.06-1.84) were independent contributing factors for shorter survival time, while received chemotherapy (HR, 0.32; 95% CI, 0.25-0.42) was an independent contributing factor better outcome. The survival days of SCLC patients with endobronchial involvement were markedly decreased compared with patients without (median 145 vs. 290, p<0.0001). Among SCLC patients of either limited (median 180 vs. 460, p<0.0001) or extensive (median 125 vs. 207, p<0.0001) stages, the median survival duration for patients with endobronchial mucosal invasion was shorter than those with intact endobronchial mucosa, respectively. Conclusion: Endobronchial mucosal involvement is an independent prognostic factor for SCLC patients and associated with decreased survival days.

UR - http://www.scopus.com/inward/record.url?scp=84867133629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867133629&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0047613

DO - 10.1371/journal.pone.0047613

M3 - Article

C2 - 23056644

AN - SCOPUS:84867133629

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e47613

ER -