Endemic Burkholderia cepacia bacteraemia

Clinical features and antimicrobial susceptibilities of isolates

Wen Liang Yu, Der Yuan Wang, Cheng Wen Lin, Mei Fen Tsou

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy (44%). Multivariate analysis revealed that indwelling central venous catheter was the significant risk factor predisposing to B. cepacia bacteraemia (p = 0.025). Eleven case-patients met the definition of catheter-related bloodstream infection. Fifteen patients (60%) received appropriate antimicrobial therapy after notification of positive blood cultures and susceptibility patterns. The overall case-fatality rate was 12% (3/25), only 1 of whom died of B. cepacia bacteraemia. There was no statistically significant difference in overall mortality rate between case-patients and controls. All isolates were susceptible to ceftazidime, piperacillin and minocycline and 84% of the isolates were susceptible to imipenem. B. cepacia should be considered a potential pathogen in hospitalized patients with severe underlying diseases, particularly those with indwelling central venous catheters.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalScandinavian Journal of Infectious Diseases
Volume31
Issue number3
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Burkholderia cepacia
Bacteremia
Indwelling Catheters
Central Venous Catheters
Catheter-Related Infections
Minocycline
Piperacillin
Ceftazidime
Mortality
Imipenem
Cross Infection
Taiwan
Cystic Fibrosis
Disease Outbreaks
China
Neoplasms
Fibrosis
Multivariate Analysis
Escherichia coli

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Endemic Burkholderia cepacia bacteraemia : Clinical features and antimicrobial susceptibilities of isolates. / Yu, Wen Liang; Wang, Der Yuan; Lin, Cheng Wen; Tsou, Mei Fen.

In: Scandinavian Journal of Infectious Diseases, Vol. 31, No. 3, 1999, p. 293-298.

Research output: Contribution to journalArticle

@article{2a73348dc01f455481a1a5bca8e5ad1d,
title = "Endemic Burkholderia cepacia bacteraemia: Clinical features and antimicrobial susceptibilities of isolates",
abstract = "Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44{\%}). Twenty-four patients (96{\%}) had nosocomial infections. Five patients (20{\%}) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy (44{\%}). Multivariate analysis revealed that indwelling central venous catheter was the significant risk factor predisposing to B. cepacia bacteraemia (p = 0.025). Eleven case-patients met the definition of catheter-related bloodstream infection. Fifteen patients (60{\%}) received appropriate antimicrobial therapy after notification of positive blood cultures and susceptibility patterns. The overall case-fatality rate was 12{\%} (3/25), only 1 of whom died of B. cepacia bacteraemia. There was no statistically significant difference in overall mortality rate between case-patients and controls. All isolates were susceptible to ceftazidime, piperacillin and minocycline and 84{\%} of the isolates were susceptible to imipenem. B. cepacia should be considered a potential pathogen in hospitalized patients with severe underlying diseases, particularly those with indwelling central venous catheters.",
author = "Yu, {Wen Liang} and Wang, {Der Yuan} and Lin, {Cheng Wen} and Tsou, {Mei Fen}",
year = "1999",
doi = "10.1080/00365549950163608",
language = "English",
volume = "31",
pages = "293--298",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Endemic Burkholderia cepacia bacteraemia

T2 - Clinical features and antimicrobial susceptibilities of isolates

AU - Yu, Wen Liang

AU - Wang, Der Yuan

AU - Lin, Cheng Wen

AU - Tsou, Mei Fen

PY - 1999

Y1 - 1999

N2 - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy (44%). Multivariate analysis revealed that indwelling central venous catheter was the significant risk factor predisposing to B. cepacia bacteraemia (p = 0.025). Eleven case-patients met the definition of catheter-related bloodstream infection. Fifteen patients (60%) received appropriate antimicrobial therapy after notification of positive blood cultures and susceptibility patterns. The overall case-fatality rate was 12% (3/25), only 1 of whom died of B. cepacia bacteraemia. There was no statistically significant difference in overall mortality rate between case-patients and controls. All isolates were susceptible to ceftazidime, piperacillin and minocycline and 84% of the isolates were susceptible to imipenem. B. cepacia should be considered a potential pathogen in hospitalized patients with severe underlying diseases, particularly those with indwelling central venous catheters.

AB - Burkholderia cepacia has emerged as a nosocomial pathogen, causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. Reports of clinical features of endemic B. cepacia bacteraemia in non-CF patients are rare. Twenty-five patients with B. cepacia bacteraemia were matched with 25 controls with nosocomial Escherichia coli bacteraemia at China Medical College Hospital, Taichung, Taiwan, over a period of 3 y. Case-patients included 16 men and 9 women, from 13 to 75 y. All had severe underlying diseases, most commonly malignancy (44%). Twenty-four patients (96%) had nosocomial infections. Five patients (20%) had polymicrobial bacteraemia. Our controls included 11 men and 14 women, age range 18-80 y. The most common underlying disease was malignancy (44%). Multivariate analysis revealed that indwelling central venous catheter was the significant risk factor predisposing to B. cepacia bacteraemia (p = 0.025). Eleven case-patients met the definition of catheter-related bloodstream infection. Fifteen patients (60%) received appropriate antimicrobial therapy after notification of positive blood cultures and susceptibility patterns. The overall case-fatality rate was 12% (3/25), only 1 of whom died of B. cepacia bacteraemia. There was no statistically significant difference in overall mortality rate between case-patients and controls. All isolates were susceptible to ceftazidime, piperacillin and minocycline and 84% of the isolates were susceptible to imipenem. B. cepacia should be considered a potential pathogen in hospitalized patients with severe underlying diseases, particularly those with indwelling central venous catheters.

UR - http://www.scopus.com/inward/record.url?scp=0032771428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032771428&partnerID=8YFLogxK

U2 - 10.1080/00365549950163608

DO - 10.1080/00365549950163608

M3 - Article

VL - 31

SP - 293

EP - 298

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 3

ER -