End stage renal disease is associated with development of dementia

Peir Haur Hung, Chih Ching Yeh, Chih Yen Hsiao, Pi Shan Sung, Chih Hsin Muo, Fung Chang Sung, Kuan Yu Hung, Kuen Jer Tsai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There is controversy regarding the extent of risk for dementia in patients with end stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). We examined data from Taiwan's Longitudinal Health Insurance Database, and used Cox proportional hazard regression analysis to compare the development of dementia in 72,934 HD and PD patients with 72,934 matched controls from January 1, 1999 to December 31, 2010. The results indicate an increased risk for dementia overall in HD patients (adjusted hazard ratio [aHR] = 1.64, p < 0.0001) and PD patients (aHR = 2.21, p < 0.0001). HD and PD patients also had significantly greater aHRs for vascular dementia (VaD) and unspecified dementia (UnD), but only HD patients had a significantly greater aHR for Alzheimer's disease (AD). Further research is needed to confirm whether management of ESRD with PD can reduce the incidence of AD, and to identify the mechanisms by which ESRD increases the risk of dementia.

Original languageEnglish
Pages (from-to)107348-107355
Number of pages8
JournalOncotarget
Volume8
Issue number64
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Chronic Kidney Failure
Peritoneal Dialysis
Dementia
Renal Dialysis
Alzheimer Disease
Vascular Dementia
Health Insurance
Taiwan
Regression Analysis
Databases
Incidence
Research

Keywords

  • Alzheimer's disease
  • Dementia
  • End stage renal disease
  • Gerotarget
  • Hemodialysis
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Oncology

Cite this

Hung, P. H., Yeh, C. C., Hsiao, C. Y., Sung, P. S., Muo, C. H., Sung, F. C., ... Tsai, K. J. (2017). End stage renal disease is associated with development of dementia. Oncotarget, 8(64), 107348-107355. https://doi.org/10.18632/oncotarget.22458

End stage renal disease is associated with development of dementia. / Hung, Peir Haur; Yeh, Chih Ching; Hsiao, Chih Yen; Sung, Pi Shan; Muo, Chih Hsin; Sung, Fung Chang; Hung, Kuan Yu; Tsai, Kuen Jer.

In: Oncotarget, Vol. 8, No. 64, 01.01.2017, p. 107348-107355.

Research output: Contribution to journalArticle

Hung, PH, Yeh, CC, Hsiao, CY, Sung, PS, Muo, CH, Sung, FC, Hung, KY & Tsai, KJ 2017, 'End stage renal disease is associated with development of dementia', Oncotarget, vol. 8, no. 64, pp. 107348-107355. https://doi.org/10.18632/oncotarget.22458
Hung PH, Yeh CC, Hsiao CY, Sung PS, Muo CH, Sung FC et al. End stage renal disease is associated with development of dementia. Oncotarget. 2017 Jan 1;8(64):107348-107355. https://doi.org/10.18632/oncotarget.22458
Hung, Peir Haur ; Yeh, Chih Ching ; Hsiao, Chih Yen ; Sung, Pi Shan ; Muo, Chih Hsin ; Sung, Fung Chang ; Hung, Kuan Yu ; Tsai, Kuen Jer. / End stage renal disease is associated with development of dementia. In: Oncotarget. 2017 ; Vol. 8, No. 64. pp. 107348-107355.
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