Encephalitis induced by a newly discovered ruminant rhadinovirus in a free-living formosan sambar deer (Rusa unicolor swinhoei)

A.-M. Chang, C.-C. Chen, C.-D. Chang, Y.-L. Huang, G.-M. Ke, B.A. Walther

Research output: Contribution to journalArticlepeer-review

Abstract

We documented a case of a free-living Formosan sambar deer (Rusa unicolor swinhoei) infected with a newly discovered ruminant Rhadinovirus (RuRv). Non-purulent encephalitis was the primary histological lesion of the sambar deer. We conducted nested PCR to screen for herpesvirus using generic primers targeting the DNA polymerase gene. In addition, we found that DNA polymerase gene of the sambar deer RuRv was present in the macrophage distributed in the Virchow Robin space with histopathologic lesions by chromogenic in-situ hybridization (CISH). The phylogenetic analysis indicated a high similarity between the viral sequence isolated from fallow deer and our case. This result suggests the possibility of cross-species transmission from other exotic Cervidae reservoir to the Formosan sambar deer. © 2018 The Japanese Society of Veterinary Science.
Original languageEnglish
Pages (from-to)810-813
Number of pages4
JournalJournal of Veterinary Medical Science
Volume80
Issue number5
DOIs
Publication statusPublished - 2018

Keywords

  • Cervidae
  • Formosan sambar deer
  • Ruminant rhadinovirus
  • animal
  • case report
  • cell line
  • classification
  • deer
  • herpes virus infection
  • isolation and purification
  • male
  • molecular typing
  • phylogeny
  • real time polymerase chain reaction
  • Rhadinovirus
  • veterinary medicine
  • virology
  • virus encephalitis
  • Animals
  • Cell Line
  • Deer
  • Encephalitis, Viral
  • Herpesviridae Infections
  • Male
  • Molecular Typing
  • Phylogeny
  • Real-Time Polymerase Chain Reaction

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