En bloc resection for lung cancer with chest wall invasion

Yu Teng Lin, Po Kuei Hsu, Han Shui Hsu, Chien Sheng Huang, Liang Shun Wang, Biing Shiun Huang, Wen Hu Hsu, Min Hsiung Huang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The aim of this study was to retrospectively assess the results of en bloc chest wall plus lung resection for patients with non-small cell lung cancer (NSCLC) invading the chest wall. Methods: From January 1986 to December 2000, of 1,820 patients having surgery for NSCLC, 42 (2.3%) patients with neoplasms involving the chest wall underwent en bloc chest wall and lung resection. Patient demographics, preoperative symptoms, operative procedures, tumor cell type and size, removed nodal status, and pathologic stage were summarized. The 5-year survival rates of the groups were compared. Results: Postoperative staging revealed 28 were T3N0M0, 4 were T3N1M0, and 10 were T3N2M0. The in-hospital mortality rate was 11.9% (5/42). The mean age was 79.0 ± 2.8 years in the patients who died of complications, which was significantly older than the mean age of 67.9 ± 8.1 years in the patients who survived the surgery (p = 0.005). The overall 5-year survival was 28.4%. The 5-year survival was significantly longer in the patients with negative (N0) nodal metastasis than in those with N1 and/or N2 nodal metastasis (39.6% versus 7.1%, p = 0.01). Eleven patients had tumor involvement of the parietal pleura. Thirty-one patients had tumor involvement of the soft tissue and/or bone. There was no significant difference of 5-year survival rate between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone (10.9% versus 33.5%, p = 0.94). Conclusion: En bloc resection for bronchogenic carcinoma invading the chest wall provides a favorable prognosis in cases without nodal metastasis. Significant postoperative mortality is associated with old age (> 80 years). The 5-year survival rate is not significantly different between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalJournal of the Chinese Medical Association
Volume69
Issue number4
Publication statusPublished - Apr 2006
Externally publishedYes

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Thoracic Wall
Lung Neoplasms
Pleura
Survival Rate
Neoplasm Metastasis
Bone and Bones
Non-Small Cell Lung Carcinoma
Neoplasms
Lung
Survival
Bronchogenic Carcinoma
Mortality
Operative Surgical Procedures
Hospital Mortality
Cell Size
Demography

Keywords

  • Chest wall
  • En bloc resection
  • Lung neoplasm

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lin, Y. T., Hsu, P. K., Hsu, H. S., Huang, C. S., Wang, L. S., Huang, B. S., ... Huang, M. H. (2006). En bloc resection for lung cancer with chest wall invasion. Journal of the Chinese Medical Association, 69(4), 157-161.

En bloc resection for lung cancer with chest wall invasion. / Lin, Yu Teng; Hsu, Po Kuei; Hsu, Han Shui; Huang, Chien Sheng; Wang, Liang Shun; Huang, Biing Shiun; Hsu, Wen Hu; Huang, Min Hsiung.

In: Journal of the Chinese Medical Association, Vol. 69, No. 4, 04.2006, p. 157-161.

Research output: Contribution to journalArticle

Lin, YT, Hsu, PK, Hsu, HS, Huang, CS, Wang, LS, Huang, BS, Hsu, WH & Huang, MH 2006, 'En bloc resection for lung cancer with chest wall invasion', Journal of the Chinese Medical Association, vol. 69, no. 4, pp. 157-161.
Lin YT, Hsu PK, Hsu HS, Huang CS, Wang LS, Huang BS et al. En bloc resection for lung cancer with chest wall invasion. Journal of the Chinese Medical Association. 2006 Apr;69(4):157-161.
Lin, Yu Teng ; Hsu, Po Kuei ; Hsu, Han Shui ; Huang, Chien Sheng ; Wang, Liang Shun ; Huang, Biing Shiun ; Hsu, Wen Hu ; Huang, Min Hsiung. / En bloc resection for lung cancer with chest wall invasion. In: Journal of the Chinese Medical Association. 2006 ; Vol. 69, No. 4. pp. 157-161.
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abstract = "Background: The aim of this study was to retrospectively assess the results of en bloc chest wall plus lung resection for patients with non-small cell lung cancer (NSCLC) invading the chest wall. Methods: From January 1986 to December 2000, of 1,820 patients having surgery for NSCLC, 42 (2.3{\%}) patients with neoplasms involving the chest wall underwent en bloc chest wall and lung resection. Patient demographics, preoperative symptoms, operative procedures, tumor cell type and size, removed nodal status, and pathologic stage were summarized. The 5-year survival rates of the groups were compared. Results: Postoperative staging revealed 28 were T3N0M0, 4 were T3N1M0, and 10 were T3N2M0. The in-hospital mortality rate was 11.9{\%} (5/42). The mean age was 79.0 ± 2.8 years in the patients who died of complications, which was significantly older than the mean age of 67.9 ± 8.1 years in the patients who survived the surgery (p = 0.005). The overall 5-year survival was 28.4{\%}. The 5-year survival was significantly longer in the patients with negative (N0) nodal metastasis than in those with N1 and/or N2 nodal metastasis (39.6{\%} versus 7.1{\%}, p = 0.01). Eleven patients had tumor involvement of the parietal pleura. Thirty-one patients had tumor involvement of the soft tissue and/or bone. There was no significant difference of 5-year survival rate between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone (10.9{\%} versus 33.5{\%}, p = 0.94). Conclusion: En bloc resection for bronchogenic carcinoma invading the chest wall provides a favorable prognosis in cases without nodal metastasis. Significant postoperative mortality is associated with old age (> 80 years). The 5-year survival rate is not significantly different between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone.",
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AU - Hsu, Po Kuei

AU - Hsu, Han Shui

AU - Huang, Chien Sheng

AU - Wang, Liang Shun

AU - Huang, Biing Shiun

AU - Hsu, Wen Hu

AU - Huang, Min Hsiung

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N2 - Background: The aim of this study was to retrospectively assess the results of en bloc chest wall plus lung resection for patients with non-small cell lung cancer (NSCLC) invading the chest wall. Methods: From January 1986 to December 2000, of 1,820 patients having surgery for NSCLC, 42 (2.3%) patients with neoplasms involving the chest wall underwent en bloc chest wall and lung resection. Patient demographics, preoperative symptoms, operative procedures, tumor cell type and size, removed nodal status, and pathologic stage were summarized. The 5-year survival rates of the groups were compared. Results: Postoperative staging revealed 28 were T3N0M0, 4 were T3N1M0, and 10 were T3N2M0. The in-hospital mortality rate was 11.9% (5/42). The mean age was 79.0 ± 2.8 years in the patients who died of complications, which was significantly older than the mean age of 67.9 ± 8.1 years in the patients who survived the surgery (p = 0.005). The overall 5-year survival was 28.4%. The 5-year survival was significantly longer in the patients with negative (N0) nodal metastasis than in those with N1 and/or N2 nodal metastasis (39.6% versus 7.1%, p = 0.01). Eleven patients had tumor involvement of the parietal pleura. Thirty-one patients had tumor involvement of the soft tissue and/or bone. There was no significant difference of 5-year survival rate between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone (10.9% versus 33.5%, p = 0.94). Conclusion: En bloc resection for bronchogenic carcinoma invading the chest wall provides a favorable prognosis in cases without nodal metastasis. Significant postoperative mortality is associated with old age (> 80 years). The 5-year survival rate is not significantly different between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone.

AB - Background: The aim of this study was to retrospectively assess the results of en bloc chest wall plus lung resection for patients with non-small cell lung cancer (NSCLC) invading the chest wall. Methods: From January 1986 to December 2000, of 1,820 patients having surgery for NSCLC, 42 (2.3%) patients with neoplasms involving the chest wall underwent en bloc chest wall and lung resection. Patient demographics, preoperative symptoms, operative procedures, tumor cell type and size, removed nodal status, and pathologic stage were summarized. The 5-year survival rates of the groups were compared. Results: Postoperative staging revealed 28 were T3N0M0, 4 were T3N1M0, and 10 were T3N2M0. The in-hospital mortality rate was 11.9% (5/42). The mean age was 79.0 ± 2.8 years in the patients who died of complications, which was significantly older than the mean age of 67.9 ± 8.1 years in the patients who survived the surgery (p = 0.005). The overall 5-year survival was 28.4%. The 5-year survival was significantly longer in the patients with negative (N0) nodal metastasis than in those with N1 and/or N2 nodal metastasis (39.6% versus 7.1%, p = 0.01). Eleven patients had tumor involvement of the parietal pleura. Thirty-one patients had tumor involvement of the soft tissue and/or bone. There was no significant difference of 5-year survival rate between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone (10.9% versus 33.5%, p = 0.94). Conclusion: En bloc resection for bronchogenic carcinoma invading the chest wall provides a favorable prognosis in cases without nodal metastasis. Significant postoperative mortality is associated with old age (> 80 years). The 5-year survival rate is not significantly different between the patients with involvement of the parietal pleura only and the patients with involvement of the parietal pleura and the soft tissue and/or bone.

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