Abstract
Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
| Original language | English |
|---|---|
| Pages (from-to) | 205-212 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 329 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- 1-Nitropyrene
- DNA adduct, Mutagenicity
- Emodin
- Polygonum cuspidatum S.
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Health, Toxicology and Mutagenesis
Cite this
Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene. / Su, Hsueh Yueh; Cherng, Shur Hueih; Chen, Chien Chung; Lee, Huei.
In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 329, No. 2, 1995, p. 205-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene
AU - Su, Hsueh Yueh
AU - Cherng, Shur Hueih
AU - Chen, Chien Chung
AU - Lee, Huei
PY - 1995
Y1 - 1995
N2 - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
AB - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
KW - 1-Nitropyrene
KW - DNA adduct, Mutagenicity
KW - Emodin
KW - Polygonum cuspidatum S.
UR - http://www.scopus.com/inward/record.url?scp=0029030412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029030412&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(95)00045-K
DO - 10.1016/0027-5107(95)00045-K
M3 - Article
VL - 329
SP - 205
EP - 212
JO - Mutation Research
JF - Mutation Research
SN - 0027-5107
IS - 2
ER -