Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su, Shur Hueih Cherng, Chien Chung Chen, Huei Lee

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume329
Issue number2
DOIs
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • 1-Nitropyrene
  • DNA adduct, Mutagenicity
  • Emodin
  • Polygonum cuspidatum S.

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis

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