Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su; Shur Hueih Cherng; Chien Chung Chen; Huei Lee

doi:10.1016/0027-5107(95)00045-K

Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

Hsueh Yueh Su, Shur Hueih Cherng, Chien Chung Chen, Huei Lee

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the ³²P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

Original language	English
Pages (from-to)	205-212
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	329
Issue number	2
DOIs	https://doi.org/10.1016/0027-5107(95)00045-K
Publication status	Published - 1995
Externally published	Yes

Keywords

1-Nitropyrene
DNA adduct, Mutagenicity
Emodin
Polygonum cuspidatum S.

ASJC Scopus subject areas

Genetics
Molecular Biology
Health, Toxicology and Mutagenesis

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title = "Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene",

abstract = "Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.",

keywords = "1-Nitropyrene, DNA adduct, Mutagenicity, Emodin, Polygonum cuspidatum S.",

author = "Su, {Hsueh Yueh} and Cherng, {Shur Hueih} and Chen, {Chien Chung} and Huei Lee",

year = "1995",

doi = "10.1016/0027-5107(95)00045-K",

language = "English",

volume = "329",

pages = "205--212",

journal = "Mutation Research",

issn = "0027-5107",

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TY - JOUR

T1 - Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene

AU - Su, Hsueh Yueh

AU - Cherng, Shur Hueih

AU - Chen, Chien Chung

AU - Lee, Huei

PY - 1995

Y1 - 1995

N2 - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

AB - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.

KW - 1-Nitropyrene

KW - DNA adduct, Mutagenicity

KW - Emodin

KW - Polygonum cuspidatum S.

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JO - Mutation Research

JF - Mutation Research

SN - 0027-5107

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