Emerging roles of epithelial-mesenchymal transition in hematological malignancies

San Chi Chen, Tsai Tsen Liao, Muh Hwa Yang

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions: Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.

Original languageEnglish
Article number37
JournalJournal of Biomedical Science
Volume25
Issue number1
DOIs
Publication statusPublished - Apr 23 2018
Externally publishedYes

Fingerprint

Epithelial-Mesenchymal Transition
Hematologic Neoplasms
Transcription Factors
Lymphoma
Cells
Neoplasms
Chemotherapy
Radiotherapy
Protein-Tyrosine Kinases
Leukemia
Neoplasm Metastasis
Chemical activation
Monoclonal Antibodies
Apoptosis
Drug Resistance
Embryonic Development
Pharmaceutical Preparations
Fibrosis
Up-Regulation
Down-Regulation

Keywords

  • Epithelial-mesenchymal transition
  • Leukemia
  • Lymphoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Emerging roles of epithelial-mesenchymal transition in hematological malignancies. / Chen, San Chi; Liao, Tsai Tsen; Yang, Muh Hwa.

In: Journal of Biomedical Science, Vol. 25, No. 1, 37, 23.04.2018.

Research output: Contribution to journalReview article

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N2 - Background: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions: Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.

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