Emerging role of vitamins d and k in modulating uremic vascular calcification: The aspect of passive calcification

Yi Chou Hs, Chien Lin Lu, Cai Mei Zheng, Ruei Ming Chen, Yuh Feng Lin, Wen Chih Liu, Tzung Hai Yen, Remy Chen, Kuo Cheng Lu

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Vascular calcification is a critical complication in patients with chronic kidney disease (CKD) because it is predictive of cardiovascular events and mortality. In addition to the traditional mechanisms associated with endothelial dysfunction and the osteoblastic transformation of vascular smooth muscle cells (VSMCs), the regulation of calcification inhibitors, such as calciprotein particles (CPPs) and matrix vesicles plays a vital role in uremic vascular calcification in CKD patients because of the high prevalence of vitamin K deficiency. Vitamin K governs the gamma-carboxylation of matrix Gla protein (MGP) for inhibiting vascular calcification, and the vitamin D binding protein receptor is related to vitamin K gene expression. For patients with chronic kidney disease, adequate use of vitamin D supplements may play a role in vascular calcification through modulation of the calciprotein particles and matrix vesicles (MVs).

Original languageEnglish
JournalNutrients
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Calciprotein particle
  • Matrix vesicle
  • Vascular calcification
  • Vitamin D
  • Vitamin K

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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