Emerging nano-carrier strategies for brain tumor drug delivery and considerations for clinical translation

David J. Lundy, Helen Nguyễn, Patrick C.H. Hsieh

Research output: Contribution to journalReview articlepeer-review

Abstract

Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and development. Here, we provide an update on nano-carrier strategies for improving brain drug delivery for treatment of brain tumors, focusing on liposomes, extracellular vesicles and biomimetic strategies as the most clinically feasible strategies. Finally, we describe the obstacles in translation of these technologies including pre-clinical models, analytical methods and regulatory issues.

Original languageEnglish
Article number1193
JournalPharmaceutics
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Blood–brain barrier
  • Brain tumor
  • Exosome
  • Glioblastoma multiforme
  • Liposome
  • Nanomedicine

ASJC Scopus subject areas

  • Pharmaceutical Science

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