Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

W. L. Yu, M. F. Lee, H. J. Tang, M. C. Chang, J. Walther-Rasmussen, Y. C. Chuang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

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Klebsiella pneumoniae
Taiwan
Disease Outbreaks
Colistin
Amino Acid Substitution
Public Health
Physicians
tigecycline

Keywords

  • Carbapenemase
  • Klebsiella pneumoniae
  • KPC-16
  • KPC-17
  • KPC-2

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan. / Yu, W. L.; Lee, M. F.; Tang, H. J.; Chang, M. C.; Walther-Rasmussen, J.; Chuang, Y. C.

In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 21, No. 4, 01.04.2015.

Research output: Contribution to journalArticle

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abstract = "We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K. pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.",
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AU - Yu, W. L.

AU - Lee, M. F.

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AU - Walther-Rasmussen, J.

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