Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system

Kumiko Sakai, Hiroshi Homma, Jen Ai Lee, Takeshi Fukushima, Tomofumi Santa, Ken Tashiro, Takeshi Iwatsubo, Kazuhiro Imai

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The rat embryonic brain was probed with anti-D-aspartic acid (D-Asp) antiserum at different stages of development. At gestational day (E) 12, weak immunoreactivity (IR) of D-Asp was apparent at the hindbrain, midbrain and caudal forebrain, whereas it became more intense and extended over the whole brain at E20. However, IR markedly decreased after parturition. In the region of the immature forebrain at an early stage of development (E12), IR was mainly a characteristic of the cytoplasm of the neuronal cells, while in the more mature hindbrain it was localized in the axonal zone. In the more differentiated forebrain at a later stage of development (E18), the IR became restricted to zones which mainly consisted of axons and processes. Consequently, in the rat central nervous system; D-Asp first emerges during embryonic development as a feature of the cytoplasm and thereafter spreads into the axonal regions of neuronal cells, before disappearing almost completely after parturition.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalBrain Research
Volume808
Issue number1
DOIs
Publication statusPublished - Oct 12 1998
Externally publishedYes

Fingerprint

D-Aspartic Acid
Prosencephalon
Rhombencephalon
Central Nervous System
Neurons
Cytoplasm
Parturition
Brain
Mesencephalon
Embryonic Development
Axons
Immune Sera

Keywords

  • Central nervous system
  • D-amino acid
  • D-aspartic acid
  • Neurogenesis
  • Neuron

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system. / Sakai, Kumiko; Homma, Hiroshi; Lee, Jen Ai; Fukushima, Takeshi; Santa, Tomofumi; Tashiro, Ken; Iwatsubo, Takeshi; Imai, Kazuhiro.

In: Brain Research, Vol. 808, No. 1, 12.10.1998, p. 65-71.

Research output: Contribution to journalArticle

Sakai, K, Homma, H, Lee, JA, Fukushima, T, Santa, T, Tashiro, K, Iwatsubo, T & Imai, K 1998, 'Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system', Brain Research, vol. 808, no. 1, pp. 65-71. https://doi.org/10.1016/S0006-8993(98)00599-X
Sakai, Kumiko ; Homma, Hiroshi ; Lee, Jen Ai ; Fukushima, Takeshi ; Santa, Tomofumi ; Tashiro, Ken ; Iwatsubo, Takeshi ; Imai, Kazuhiro. / Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system. In: Brain Research. 1998 ; Vol. 808, No. 1. pp. 65-71.
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