Emergence of an S gene mutant during thymosin α1 therapy in a patient with chronic hepatitis B

Jui-Hsiang Tang, Chau Ting Yeh, Tse Ching Chen, Sen Yung Hsieh, Chia Ming Chu, Yun Fan Liaw

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The presence of a hepatitis B virus S gene mutant was investigated in a patient being treated with thymosin α1. He was seropositive for hepatitis B e antigen throughout therapy but was intermittently seronegative for hepatitis B surface antigen (HBsAg) by an RIA. Sequence analysis revealed an S gene mutant in HBsAg-seronegative serum with two consecutive amino acid substitutions: threonine115-to-isoleucine and threonine116-to- asparagine, whereas no amino acid substitution or deletion was found in the pre-S region. A site-directed mutagenesis experiment confirmed that these mutations were responsible for the failure to detect HBsAg. In summary, an S gene mutant was identified in an HBsAg-seronegative patient. The mutations were located outside the putative 'a' determinant. The emergence of an S gene mutant during thymosin α1 treatment suggests that enhanced host immunity against HBsAg may play a role in its antiviral activity.

Original languageEnglish
Pages (from-to)866-869
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number3
DOIs
Publication statusPublished - Jan 1 1998
Externally publishedYes

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Thymosin
Chronic Hepatitis B
Hepatitis B Surface Antigens
Genes
Amino Acid Substitution
Therapeutics
Mutation
Hepatitis B e Antigens
Isoleucine
Asparagine
Site-Directed Mutagenesis
Hepatitis B virus
Antiviral Agents
Sequence Analysis
Immunity
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Emergence of an S gene mutant during thymosin α1 therapy in a patient with chronic hepatitis B. / Tang, Jui-Hsiang; Yeh, Chau Ting; Chen, Tse Ching; Hsieh, Sen Yung; Chu, Chia Ming; Liaw, Yun Fan.

In: Journal of Infectious Diseases, Vol. 178, No. 3, 01.01.1998, p. 866-869.

Research output: Contribution to journalArticle

Tang, Jui-Hsiang ; Yeh, Chau Ting ; Chen, Tse Ching ; Hsieh, Sen Yung ; Chu, Chia Ming ; Liaw, Yun Fan. / Emergence of an S gene mutant during thymosin α1 therapy in a patient with chronic hepatitis B. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 3. pp. 866-869.
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