Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor

Chung Lan Kao, Shih Hwa Chiou, Donald Ming Tak Ho, Yann Jang Chen, Ren Shyan Liu, Chih Wen Lo, Fu Ting Tsai, Chi Hung Lin, Hung Hai Ku, Shang Ming Yu, Tai-Tong Wong

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Osteopontin, a cancer metastasis-associated gene, is specifically up-regulated in central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT), but its biological behavior in the progression of CNS AT/RT has never been studied. We obtained plasma, cerebrospinal fluid (CSF), and brain tissue specimens from lobectomy of hemispherectomy samples from 39 patients (medulloblastoma, 16; AT/RT, 8; epilepsy, 6; hydrocephalus, 9). By enzyme-linked immunosorbent assay, the median osteopontin levels in plasma and CSF in AT/RT (852.0 and 1,175.0 ng/mL, respectively) were significantly higher than in medulloblastoma (492.5 and 524.5 ng/mL, respectively) and hydrocephalus and epilepsy (208.0 and 168.0 ng/mL, respectively) (P < .05). The results of real-time reverse transcriptase-polymerase chain reaction and immunohistochemical analysis demonstrated that osteopontin expression in AT/RT (n = 5) was significantly higher than in medulloblastoma (n = 8) samples. The differences in osteopontin expression in plasma, CSF, and tumor samples in AT/RT and medulloblastoma correlated with survival differences. In 5 patients with AT/RT, plasma osteopontin levels decreased after treatment but increased with relapse. Osteopontin might be a potential marker to aid in identifying AT/RT recurrence.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume123
Issue number2
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

Fingerprint

Osteopontin
Cerebrospinal Fluid
Medulloblastoma
Hydrocephalus
Epilepsy
Central Nervous System
Hemispherectomy
Recurrence
Typical Teratoid Rhabdoid Tumor
Atypical Teratoid Tumor
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Neoplasms
Enzyme-Linked Immunosorbent Assay
Neoplasm Metastasis
Survival
Brain

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Medulloblastoma
  • Osteopontin
  • Primitive neuroectodermal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. / Kao, Chung Lan; Chiou, Shih Hwa; Ho, Donald Ming Tak; Chen, Yann Jang; Liu, Ren Shyan; Lo, Chih Wen; Tsai, Fu Ting; Lin, Chi Hung; Ku, Hung Hai; Yu, Shang Ming; Wong, Tai-Tong.

In: American Journal of Clinical Pathology, Vol. 123, No. 2, 01.01.2005, p. 297-304.

Research output: Contribution to journalArticle

Kao, Chung Lan ; Chiou, Shih Hwa ; Ho, Donald Ming Tak ; Chen, Yann Jang ; Liu, Ren Shyan ; Lo, Chih Wen ; Tsai, Fu Ting ; Lin, Chi Hung ; Ku, Hung Hai ; Yu, Shang Ming ; Wong, Tai-Tong. / Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. In: American Journal of Clinical Pathology. 2005 ; Vol. 123, No. 2. pp. 297-304.
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