Elevated plasma stromal cell-derived factor 1 protein and its gene polymorphism in patients with pelvic inflammatory disease

Hsiu Ting Tsai, Yi Torng Tee, Yi Hsien Hsieh, Hui Ling Chiou, Chiao Wen Lin, Hsiu Chen Tsai, Po Hui Wang, Shun Fa Yang

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6 Citations (Scopus)

Abstract

The objective was to compare the expression of plasma stromal cell-derived factor 1 and the gene polymorphism in patients with pelvic inflammatory disease and healthy controls. The enzyme-linked immunosorbent assay and polymerase chain reactionĝ€"restriction fragment length polymorphism were, respectively, used to measure the plasma stromal cell-derived factor 1AZ± level and stromal cell-derived factor 1 polymorphism in 50 healthy controls and in 44 patients with pelvic inflammatory disease before and after they received routine treatment protocols. The level of plasma stromal cell-derived factor 1AZ± was elevated in patients with pelvic inflammatory disease compared to normal controls and decreased significantly after treatment. There were significant correlations between plasma stromal cell-derived factor 1AZ± level and neutrophil count as well as between stromal cell-derived factor 1AZ± level and white blood cell count in patients with pelvic inflammatory disease. There was no significantly different distribution of stromal cell-derived factor 1 genotypes between patients with pelvic inflammatory disease and normal controls. Patients with pelvic inflammatory disease having stromal cell-derived factor 1-3'A allele were associated with significantly elevated plasma stromal cell-derived factor 1AZ± concentration compared to patients with pelvic inflammatory disease having G/G homozygous alleles (P

Original languageEnglish
Pages (from-to)610-617
Number of pages8
JournalReproductive Sciences
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 2009
Externally publishedYes

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Keywords

  • Pelvic inflammatory disease (PID)
  • Single-nucleotide polymorphism (SNP)
  • Stromal cell-derived factor 1 (SDF-1)

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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