Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes

An-Chi Lin, Hao-Chang Hung, Yun-Wen Chen, Kai-Pi Cheng, Chung-Hao Li, Ching-Han Lin, Chih-Jen Chang, Hung-Tsung Wu, Horng-Yih Ou

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of cancers. In order to prevent diabetes, early diagnosis of prediabetes is important. However, biomarkers for prediabetes diagnosis are still scarce. The hedgehog-interacting protein (Hhip) is important in embryogenesis and is known to be a biomarker of several cancers. However, Hhip levels in subjects with diabetes are still unknown.

METHODS: In total, 314 participants were enrolled and divided into normal glucose tolerance (NGT; n = 75), impaired fasting glucose (IFG; n = 66), impaired glucose tolerance (IGT; n = 86), and newly diagnosed diabetes (NDD; n = 87) groups. Plasma Hhip levels were determined by an ELISA. The association between the Hhip and the presence of diabetes was examined by a multivariate linear regression analysis.

RESULTS: There were significant differences in the body mass index, systolic and diastolic blood pressure, fasting plasma glucose (FPG), post-load 2-h glucose, hemoglobin A1c (A1C), C-reactive protein, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterol levels among the groups. Concentrations of the Hhip were 2.45 ± 2.12, 4.40 ± 3.22, 4.44 ± 3.64, and 6.31 ± 5.35 ng/mL in subjects in the NGT, IFG, IGT, and NDD groups, respectively. In addition, we found that A1C and FPG were independently associated with Hhip concentrations. Using NGT as a reference group, IFG, IGT, and NDD were all independently associated with Hhip concentrations.

CONCLUSIONS: Hhip was positively associated with prediabetes and type 2 diabetes mellitus.

Original languageEnglish
JournalJournal of Clinical Medicine
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 6 2019

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Hedgehog Proteins
Prediabetic State
Type 2 Diabetes Mellitus
Glucose
Fasting
Blood Pressure
Glucose Intolerance
Tumor Biomarkers
C-Reactive Protein
LDL Cholesterol
Embryonic Development
Blood Proteins
Early Diagnosis
Linear Models
Hemoglobins
Triglycerides
Body Mass Index
Biomarkers
Enzyme-Linked Immunosorbent Assay
Cholesterol

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Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes. / Lin, An-Chi; Hung, Hao-Chang; Chen, Yun-Wen; Cheng, Kai-Pi; Li, Chung-Hao; Lin, Ching-Han; Chang, Chih-Jen; Wu, Hung-Tsung; Ou, Horng-Yih.

In: Journal of Clinical Medicine, Vol. 8, No. 10, 06.10.2019.

Research output: Contribution to journalArticle

Lin, A-C, Hung, H-C, Chen, Y-W, Cheng, K-P, Li, C-H, Lin, C-H, Chang, C-J, Wu, H-T & Ou, H-Y 2019, 'Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes', Journal of Clinical Medicine, vol. 8, no. 10. https://doi.org/10.3390/jcm8101635
Lin, An-Chi ; Hung, Hao-Chang ; Chen, Yun-Wen ; Cheng, Kai-Pi ; Li, Chung-Hao ; Lin, Ching-Han ; Chang, Chih-Jen ; Wu, Hung-Tsung ; Ou, Horng-Yih. / Elevated Hedgehog-Interacting Protein Levels in Subjects with Prediabetes and Type 2 Diabetes. In: Journal of Clinical Medicine. 2019 ; Vol. 8, No. 10.
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AU - Lin, An-Chi

AU - Hung, Hao-Chang

AU - Chen, Yun-Wen

AU - Cheng, Kai-Pi

AU - Li, Chung-Hao

AU - Lin, Ching-Han

AU - Chang, Chih-Jen

AU - Wu, Hung-Tsung

AU - Ou, Horng-Yih

PY - 2019/10/6

Y1 - 2019/10/6

N2 - BACKGROUND: The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of cancers. In order to prevent diabetes, early diagnosis of prediabetes is important. However, biomarkers for prediabetes diagnosis are still scarce. The hedgehog-interacting protein (Hhip) is important in embryogenesis and is known to be a biomarker of several cancers. However, Hhip levels in subjects with diabetes are still unknown.METHODS: In total, 314 participants were enrolled and divided into normal glucose tolerance (NGT; n = 75), impaired fasting glucose (IFG; n = 66), impaired glucose tolerance (IGT; n = 86), and newly diagnosed diabetes (NDD; n = 87) groups. Plasma Hhip levels were determined by an ELISA. The association between the Hhip and the presence of diabetes was examined by a multivariate linear regression analysis.RESULTS: There were significant differences in the body mass index, systolic and diastolic blood pressure, fasting plasma glucose (FPG), post-load 2-h glucose, hemoglobin A1c (A1C), C-reactive protein, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterol levels among the groups. Concentrations of the Hhip were 2.45 ± 2.12, 4.40 ± 3.22, 4.44 ± 3.64, and 6.31 ± 5.35 ng/mL in subjects in the NGT, IFG, IGT, and NDD groups, respectively. In addition, we found that A1C and FPG were independently associated with Hhip concentrations. Using NGT as a reference group, IFG, IGT, and NDD were all independently associated with Hhip concentrations.CONCLUSIONS: Hhip was positively associated with prediabetes and type 2 diabetes mellitus.

AB - BACKGROUND: The prevalence of diabetes is rapidly increasing worldwide and is highly associated with the incidence of cancers. In order to prevent diabetes, early diagnosis of prediabetes is important. However, biomarkers for prediabetes diagnosis are still scarce. The hedgehog-interacting protein (Hhip) is important in embryogenesis and is known to be a biomarker of several cancers. However, Hhip levels in subjects with diabetes are still unknown.METHODS: In total, 314 participants were enrolled and divided into normal glucose tolerance (NGT; n = 75), impaired fasting glucose (IFG; n = 66), impaired glucose tolerance (IGT; n = 86), and newly diagnosed diabetes (NDD; n = 87) groups. Plasma Hhip levels were determined by an ELISA. The association between the Hhip and the presence of diabetes was examined by a multivariate linear regression analysis.RESULTS: There were significant differences in the body mass index, systolic and diastolic blood pressure, fasting plasma glucose (FPG), post-load 2-h glucose, hemoglobin A1c (A1C), C-reactive protein, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterol levels among the groups. Concentrations of the Hhip were 2.45 ± 2.12, 4.40 ± 3.22, 4.44 ± 3.64, and 6.31 ± 5.35 ng/mL in subjects in the NGT, IFG, IGT, and NDD groups, respectively. In addition, we found that A1C and FPG were independently associated with Hhip concentrations. Using NGT as a reference group, IFG, IGT, and NDD were all independently associated with Hhip concentrations.CONCLUSIONS: Hhip was positively associated with prediabetes and type 2 diabetes mellitus.

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DO - 10.3390/jcm8101635

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VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 10

ER -