Elevated E 2

Oocyte ratio in women undergoing IVF and tubal ET: Correlation with a decrease in the implantation rate

Jehn Hsiahn Yang, Hsin Fu Chen, Yih Ron Lien, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the influence of various estradiol (E 2 ):oocyte ratios on reproductive outcome in women undergoing in vitro fertilization and tubal embryo transfer (IVF-TET). STUDY DESIGN: Two hundred seven women undergoing 251 IVF-TET cycles were recruited in this retrospective study. All the women received a flare-up gonadotropin releasing hormone agonist (GnRHa) protocol to achieve ovarian hyperstimulation. Oocyte retrieval was performed 34-36 hours after human chorionic gonadotropin (hCG) injection, followed by TET two days later. RESULTS: An E 2 :oocyte ratio ≥ 350 pg/mL had a higher E 2 level (2,213 ± 2,258 vs. 1,553 ± 972 pg/mL, P < .05) and fertilization rate (77 ± 23 vs. 64 ± 23%, P < .001) but a lower oocyte number (4.8 ± 4.7. vs. 7.6 ± 4.8, P < .001) than in those with a ratio < 350 pg/mL. The pregnancy (17.9% vs. 32.8%, P=.03) and implantation (5.3% vs. 12.9%, P =.008) rates were significantly decreased in cycles with an E2:oocyte ratio ≥ 350 pg/mL as compared to those with a ratio < 350 pg/mL. CONCLUSION: IVF-TET cycles with an elevated E 2 :oocyte ratio correlated with lower pregnancy and implantation rates. The poor reproductive outcome possibly was due to the relatively high E 2 concentration, which might have a detrimental effect on endometrial receptivity.

Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume46
Issue number5
Publication statusPublished - May 1 2001
Externally publishedYes

Fingerprint

Buserelin
Menotropins
Embryo Transfer
Follicle Stimulating Hormone
Chorionic Gonadotropin
Fertilization in Vitro
Oocytes
Estradiol
Retrospective Studies
Cell Count
Pregnancy
Oocyte Retrieval
Pregnancy Rate
Fertilization
Gonadotropin-Releasing Hormone
Injections

Keywords

  • Embryo transfer
  • Estradiol
  • Fertilization in vitro
  • Oocytes
  • Ovum implantation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Elevated E 2 : Oocyte ratio in women undergoing IVF and tubal ET: Correlation with a decrease in the implantation rate. / Yang, Jehn Hsiahn; Chen, Hsin Fu; Lien, Yih Ron; Chen, Shee Uan; Ho, Hong Nerng; Yang, Yu Shih.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 46, No. 5, 01.05.2001, p. 434-438.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To investigate the influence of various estradiol (E 2 ):oocyte ratios on reproductive outcome in women undergoing in vitro fertilization and tubal embryo transfer (IVF-TET). STUDY DESIGN: Two hundred seven women undergoing 251 IVF-TET cycles were recruited in this retrospective study. All the women received a flare-up gonadotropin releasing hormone agonist (GnRHa) protocol to achieve ovarian hyperstimulation. Oocyte retrieval was performed 34-36 hours after human chorionic gonadotropin (hCG) injection, followed by TET two days later. RESULTS: An E 2 :oocyte ratio ≥ 350 pg/mL had a higher E 2 level (2,213 ± 2,258 vs. 1,553 ± 972 pg/mL, P < .05) and fertilization rate (77 ± 23 vs. 64 ± 23{\%}, P < .001) but a lower oocyte number (4.8 ± 4.7. vs. 7.6 ± 4.8, P < .001) than in those with a ratio < 350 pg/mL. The pregnancy (17.9{\%} vs. 32.8{\%}, P=.03) and implantation (5.3{\%} vs. 12.9{\%}, P =.008) rates were significantly decreased in cycles with an E2:oocyte ratio ≥ 350 pg/mL as compared to those with a ratio < 350 pg/mL. CONCLUSION: IVF-TET cycles with an elevated E 2 :oocyte ratio correlated with lower pregnancy and implantation rates. The poor reproductive outcome possibly was due to the relatively high E 2 concentration, which might have a detrimental effect on endometrial receptivity.",
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