Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

Yi Fang Tu, Chih Hao Lin, Hsueh Te Lee, Jing Jou Yan, Chun I. Sze, Ya Ping Chou, Chien Jung Ho, Chao Ching Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)


Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p

Original languageEnglish
Pages (from-to)e105-e111
JournalInternational Journal of Infectious Diseases
Publication statusPublished - May 1 2015



  • Encephalitis
  • Endothelin 1
  • Enterovirus 71
  • Neurogenic pulmonary edema

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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