Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

Yi Fang Tu, Chih Hao Lin, Hsueh Te Lee, Jing Jou Yan, Chun I. Sze, Ya Ping Chou, Chien Jung Ho, Chao Ching Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p

Original languageEnglish
Pages (from-to)e105-e111
JournalInternational Journal of Infectious Diseases
Volume34
DOIs
Publication statusPublished - May 1 2015

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Enterovirus
Endothelin-1
Pulmonary Edema
Encephalitis
Cerebrospinal Fluid
Aseptic Meningitis
Spinal Injections
Vasoconstrictor Agents
Brain Stem
Autopsy
Central Nervous System

Keywords

  • Encephalitis
  • Endothelin 1
  • Enterovirus 71
  • Neurogenic pulmonary edema

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis. / Tu, Yi Fang; Lin, Chih Hao; Lee, Hsueh Te; Yan, Jing Jou; Sze, Chun I.; Chou, Ya Ping; Ho, Chien Jung; Huang, Chao Ching.

In: International Journal of Infectious Diseases, Vol. 34, 01.05.2015, p. e105-e111.

Research output: Contribution to journalArticle

Tu, Yi Fang ; Lin, Chih Hao ; Lee, Hsueh Te ; Yan, Jing Jou ; Sze, Chun I. ; Chou, Ya Ping ; Ho, Chien Jung ; Huang, Chao Ching. / Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis. In: International Journal of Infectious Diseases. 2015 ; Vol. 34. pp. e105-e111.
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AU - Yan, Jing Jou

AU - Sze, Chun I.

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AU - Ho, Chien Jung

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