Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu; Yu Chen Wang; Long Sheng Lu; Brian Walton; H. Ramazan Yilmaz; Roger Y. Huang; Tatsuya Sawamura; Richard A F Dixon; Wen Ter Lai; Chu Huang Chen; Jonathan Lu

doi:10.1371/journal.pone.0070533

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu, Yu Chen Wang, Long Sheng Lu, Brian Walton, H. Ramazan Yilmaz, Roger Y. Huang, Tatsuya Sawamura, Richard A F Dixon, Wen Ter Lai, Chu Huang Chen, Jonathan Lu

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

Original language	English
Article number	e70533
Journal	PLoS One
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0070533
Publication status	Published - Aug 8 2013
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Chu, C. S., Wang, Y. C., Lu, L. S., Walton, B., Yilmaz, H. R., Huang, R. Y., Sawamura, T., Dixon, R. A. F., Lai, W. T., Chen, C. H., & Lu, J. (2013). Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. PLoS One, 8(8), [e70533]. https://doi.org/10.1371/journal.pone.0070533

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. / Chu, Chih Sheng; Wang, Yu Chen; Lu, Long Sheng; Walton, Brian; Yilmaz, H. Ramazan; Huang, Roger Y.; Sawamura, Tatsuya; Dixon, Richard A F; Lai, Wen Ter; Chen, Chu Huang; Lu, Jonathan.

In: PLoS One, Vol. 8, No. 8, e70533, 08.08.2013.

Research output: Contribution to journal › Article

Chu, Chih Sheng ; Wang, Yu Chen ; Lu, Long Sheng ; Walton, Brian ; Yilmaz, H. Ramazan ; Huang, Roger Y. ; Sawamura, Tatsuya ; Dixon, Richard A F ; Lai, Wen Ter ; Chen, Chu Huang ; Lu, Jonathan. / Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. In: PLoS One. 2013 ; Vol. 8, No. 8.

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abstract = "Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P",

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