Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu, Yu Chen Wang, Long Sheng Lu, Brian Walton, H. Ramazan Yilmaz, Roger Y. Huang, Tatsuya Sawamura, Richard A F Dixon, Wen Ter Lai, Chu Huang Chen, Jonathan Lu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

Original languageEnglish
Article numbere70533
JournalPLoS One
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 8 2013
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Chu, C. S., Wang, Y. C., Lu, L. S., Walton, B., Yilmaz, H. R., Huang, R. Y., Sawamura, T., Dixon, R. A. F., Lai, W. T., Chen, C. H., & Lu, J. (2013). Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. PLoS One, 8(8), [e70533]. https://doi.org/10.1371/journal.pone.0070533