Abstract
Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P
| Original language | English |
|---|---|
| Article number | e70533 |
| Journal | PLoS One |
| Volume | 8 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 8 2013 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. / Chu, Chih Sheng; Wang, Yu Chen; Lu, Long Sheng; Walton, Brian; Yilmaz, H. Ramazan; Huang, Roger Y.; Sawamura, Tatsuya; Dixon, Richard A F; Lai, Wen Ter; Chen, Chu Huang; Lu, Jonathan.
In: PLoS One, Vol. 8, No. 8, e70533, 08.08.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor
AU - Chu, Chih Sheng
AU - Wang, Yu Chen
AU - Lu, Long Sheng
AU - Walton, Brian
AU - Yilmaz, H. Ramazan
AU - Huang, Roger Y.
AU - Sawamura, Tatsuya
AU - Dixon, Richard A F
AU - Lai, Wen Ter
AU - Chen, Chu Huang
AU - Lu, Jonathan
PY - 2013/8/8
Y1 - 2013/8/8
N2 - Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P
AB - Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P
UR - http://www.scopus.com/inward/record.url?scp=84881345898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881345898&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0070533
DO - 10.1371/journal.pone.0070533
M3 - Article
C2 - 23950953
AN - SCOPUS:84881345898
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 8
M1 - e70533
ER -