Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

Chih Sheng Chu, Yu Chen Wang, Long Sheng Lu, Brian Walton, H. Ramazan Yilmaz, Roger Y. Huang, Tatsuya Sawamura, Richard A F Dixon, Wen Ter Lai, Chu Huang Chen, Jonathan Lu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objectives:Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, which is atherogenic to ECs. Because L5 and CRP are both ligands for the lectin-like oxidized LDL receptor-1 (LOX-1), we also examined the role of LOX-1.Methods and Results:Plasma LDL samples isolated from asymptomatic hypercholesterolemic (LDL cholesterol [LDL-C] levels, 154.6±20 mg/dL; n = 7) patients and normocholesterolemic (LDL-C levels, 86.1±21 mg/dL; P

Original languageEnglish
Article numbere70533
JournalPLoS One
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 8 2013
Externally publishedYes

Fingerprint

Oxidized LDL Receptors
C-reactive protein
Endothelial cells
low density lipoprotein
LDL Lipoproteins
blood vessels
C-Reactive Protein
endothelial cells
Endothelial Cells
protein synthesis
receptors
Class E Scavenger Receptors
Plasmas
Acute Coronary Syndrome
LDL Cholesterol
Blood Proteins
low density lipoprotein cholesterol
lectins
Ligands
blood proteins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. / Chu, Chih Sheng; Wang, Yu Chen; Lu, Long Sheng; Walton, Brian; Yilmaz, H. Ramazan; Huang, Roger Y.; Sawamura, Tatsuya; Dixon, Richard A F; Lai, Wen Ter; Chen, Chu Huang; Lu, Jonathan.

In: PLoS One, Vol. 8, No. 8, e70533, 08.08.2013.

Research output: Contribution to journalArticle

Chu, CS, Wang, YC, Lu, LS, Walton, B, Yilmaz, HR, Huang, RY, Sawamura, T, Dixon, RAF, Lai, WT, Chen, CH & Lu, J 2013, 'Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor', PLoS One, vol. 8, no. 8, e70533. https://doi.org/10.1371/journal.pone.0070533
Chu, Chih Sheng ; Wang, Yu Chen ; Lu, Long Sheng ; Walton, Brian ; Yilmaz, H. Ramazan ; Huang, Roger Y. ; Sawamura, Tatsuya ; Dixon, Richard A F ; Lai, Wen Ter ; Chen, Chu Huang ; Lu, Jonathan. / Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor. In: PLoS One. 2013 ; Vol. 8, No. 8.
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AU - Yilmaz, H. Ramazan

AU - Huang, Roger Y.

AU - Sawamura, Tatsuya

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