Electrocorticography to Investigate Age-Related Brain Lateralization on Pediatric Motor Inhibition

Chao Hung Kuo, Kaitlyn Casimo, Jing Wu, Kelly Collins, Patrick Rice, Bo Wei Chen, Shih Hung Yang, Yu Chun Lo, Edward J. Novotny, Kurt E. Weaver, You Yin Chen, Jeffrey G. Ojemann

Research output: Contribution to journalArticlepeer-review

Abstract

Response inhibition refers to the ability to suppress inappropriate actions that interfere with goal-driven behavior. The inferior frontal gyrus (IFG) is known to be associated with inhibition of a motor response by assuming executive control over motor cortex outputs. This study aimed to evaluate the pediatric development of response inhibition through subdural electrocorticography (ECoG) recording. Subdural ECoG recorded neural activities simultaneously during a Go/No-Go task, which was optimized for children. Different frequency power [theta: 4–8 Hz; beta: 12–40 Hz; high-gamma (HG): 70–200 Hz] was estimated within the IFG and motor cortex. Age-related analysis was computed by each bandpass power ratio between Go and No-Go conditions, and phase-amplitude coupling (PAC) over IFG by using the modulating index metric in two conditions. For all the eight pediatric patients, HG power was more activated in No-Go trials than in Go trials, in either right- or left-side IFG when available. In the IFG region, the power over theta and HG in No-Go conditions was higher than those in Go conditions, with significance over the right side (p < 0.05). The age-related lateralization from both sides to the right side was observed from the ratio of HG power and PAC value between the No-Go and Go trials. In the pediatric population, the role of motor inhibition was observed in both IFG, with age-related lateralization to the right side, which was proved in the previous functional magnetic resonance imaging studies. In this study, the evidence correlation of age and response inhibition was observed directly by the evidence of cortical recordings.

Original languageEnglish
Article number747053
JournalFrontiers in Neurology
Volume13
DOIs
Publication statusPublished - Mar 7 2022

Keywords

  • electrocorticography
  • Go/No-Go
  • high-gamma
  • inferior frontal gyrus
  • lateralization
  • motor inhibition

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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