Electrocorticography in patients with medically intractable temporal lobe seizures. I. Quantification of epileptiform discharges prior to resective surgery

Min Lan Tsai, Gian Emilio Chatrian, Flavia Pauri, Nancy R. Temkin, Ann L. Holubkov, Cheng Mei Shaw, George A. Ojemann

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We studied retrospectively the intraoperative preresection electrocorticograms (ECoGs) of 72 patients undergoing surgery for medically intractable, mostly complex partial, temporal lobe seizures (TLS). Quantification of interictal epileptiform discharges (EDs) detected visually at each electrode location in 2 min recording epochs included computations of ED rates (EDs/min) and cumulative voltages (CuVs) (μV/min). Of 6388 EDs, 81% involved the infratemporal surface, 18% the lateral temporal surface and 1% the orbital frontal area. Forty-eight patients (67%) demonstrated multiple (up to 5 or more), temporally independent foci. Dominant foci in medial and lateral infratemporal locations were about equally common and were significantly more frequent than in lateral temporal locations. Rankings of ED CuVs and rates at individual cortical locations defined 4 areas of "relative interictal cortical epileptogenicity." These were arranged in an orderly pattern with the anterior parahippocampal gyrus and the inferomedial surface of the temporal tip displaying the highest and the lateral temporal and posterior infratemporal cortices showing the lowest propensity to the interictal epileptiform discharge. Individual areas were not characterized by distinct clinical seizure manifestations. Preresection ECoGs provide information on the epileptogenic dysfunction that involves most of the temporal lobe of patients with medically intractable TLS.

Original languageEnglish
Pages (from-to)10-24
Number of pages15
JournalElectroencephalography and Clinical Neurophysiology
Volume87
Issue number1
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

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Temporal Lobe
Seizures
Parahippocampal Gyrus
Prefrontal Cortex
Electrodes
Electrocorticography

Keywords

  • Complex partial seizures
  • Preresection electrocorticogram
  • Scalp/basal EEGs
  • Subdural strip recordings
  • Temporal lobe seizures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Electrocorticography in patients with medically intractable temporal lobe seizures. I. Quantification of epileptiform discharges prior to resective surgery. / Tsai, Min Lan; Chatrian, Gian Emilio; Pauri, Flavia; Temkin, Nancy R.; Holubkov, Ann L.; Shaw, Cheng Mei; Ojemann, George A.

In: Electroencephalography and Clinical Neurophysiology, Vol. 87, No. 1, 01.01.1993, p. 10-24.

Research output: Contribution to journalArticle

Tsai, Min Lan ; Chatrian, Gian Emilio ; Pauri, Flavia ; Temkin, Nancy R. ; Holubkov, Ann L. ; Shaw, Cheng Mei ; Ojemann, George A. / Electrocorticography in patients with medically intractable temporal lobe seizures. I. Quantification of epileptiform discharges prior to resective surgery. In: Electroencephalography and Clinical Neurophysiology. 1993 ; Vol. 87, No. 1. pp. 10-24.
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