Electrochemical polymerization of PEDOT-graphene oxide-heparin composite coating for anti-fouling and anti-clotting of cardiovascular stents

Ming Chien Yang, Hui Ming Tsou, Yu Sheng Hsiao, Yu Wei Cheng, Che Chun Liu, Li Ying Huang, Xin Yao Peng, Ting Yu Liu, Ming Chi Yung, Chuan Chih Hsu

Research output: Contribution to journalArticle

Abstract

In this study, a novel hemocompatible coating on stainless steel substrates was prepared by electrochemically copolymerizing 3,4-ethylenedioxythiophene (EDOT) with graphene oxide (GO), polystyrene sulfonate (PSS), or heparin (HEP) on SUS316L stainless steel, producing an anti-fouling (anti-protein adsorption and anti-platelet adhesion) surface to avoid the restenosis of blood vessels. The negative charges of GO, PSS, and HEP repel negatively charged proteins and platelets to achieve anti-fouling and anti-clotting. The results show that the anti-fouling capability of the poly(3,4-ethylenedioxythiophene) (PEDOT)/PSS coating is similar to that of the PEDOT/HEP coating. The anti-fouling capability of PEDOT/GO is higher than those of PEDOT/HEP and PEDOT/PSS. The reason for this is that GO exhibits negatively charged functional groups (COO-). The highest anti-fouling capability was found with the PEDOT/GO/HEP coating, indicating that electrochemical copolymerization of PEDOT with GO and HEP enhances the anti-fouling capability. Furthermore, the biocompatibility of the PEDOT coatings was tested with 3T3 cells for 1-5 days. The results show that all PEDOT composite coatings exhibited biocompatibility. The blood clotting time (APTT) of PEDOT/GO/HEP was prolonged to 225 s, much longer than the 40 s of pristine SUS316L stainless steel (the control), thus greatly improving the anti-blood-clotting capability of cardiovascular stents.

Original languageEnglish
Article number1520
JournalPolymers
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Stents
Graphite
Electropolymerization
Composite coatings
Fouling
Oxides
Graphene
Heparin
Polystyrenes
Coatings
Stainless steel
Stainless Steel
Platelets
Biocompatibility
Blood
Proteins
Blood vessels
poly(3,4-ethylene dioxythiophene)
Copolymerization
Functional groups

Keywords

  • Anti-fouling
  • Anticlotting
  • Biocompatibility
  • Electrochemical polymerization
  • PEDOT
  • SUS316L

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Cite this

Electrochemical polymerization of PEDOT-graphene oxide-heparin composite coating for anti-fouling and anti-clotting of cardiovascular stents. / Yang, Ming Chien; Tsou, Hui Ming; Hsiao, Yu Sheng; Cheng, Yu Wei; Liu, Che Chun; Huang, Li Ying; Peng, Xin Yao; Liu, Ting Yu; Yung, Ming Chi; Hsu, Chuan Chih.

In: Polymers, Vol. 11, No. 9, 1520, 01.09.2019.

Research output: Contribution to journalArticle

Yang, Ming Chien ; Tsou, Hui Ming ; Hsiao, Yu Sheng ; Cheng, Yu Wei ; Liu, Che Chun ; Huang, Li Ying ; Peng, Xin Yao ; Liu, Ting Yu ; Yung, Ming Chi ; Hsu, Chuan Chih. / Electrochemical polymerization of PEDOT-graphene oxide-heparin composite coating for anti-fouling and anti-clotting of cardiovascular stents. In: Polymers. 2019 ; Vol. 11, No. 9.
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abstract = "In this study, a novel hemocompatible coating on stainless steel substrates was prepared by electrochemically copolymerizing 3,4-ethylenedioxythiophene (EDOT) with graphene oxide (GO), polystyrene sulfonate (PSS), or heparin (HEP) on SUS316L stainless steel, producing an anti-fouling (anti-protein adsorption and anti-platelet adhesion) surface to avoid the restenosis of blood vessels. The negative charges of GO, PSS, and HEP repel negatively charged proteins and platelets to achieve anti-fouling and anti-clotting. The results show that the anti-fouling capability of the poly(3,4-ethylenedioxythiophene) (PEDOT)/PSS coating is similar to that of the PEDOT/HEP coating. The anti-fouling capability of PEDOT/GO is higher than those of PEDOT/HEP and PEDOT/PSS. The reason for this is that GO exhibits negatively charged functional groups (COO-). The highest anti-fouling capability was found with the PEDOT/GO/HEP coating, indicating that electrochemical copolymerization of PEDOT with GO and HEP enhances the anti-fouling capability. Furthermore, the biocompatibility of the PEDOT coatings was tested with 3T3 cells for 1-5 days. The results show that all PEDOT composite coatings exhibited biocompatibility. The blood clotting time (APTT) of PEDOT/GO/HEP was prolonged to 225 s, much longer than the 40 s of pristine SUS316L stainless steel (the control), thus greatly improving the anti-blood-clotting capability of cardiovascular stents.",
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AU - Yang, Ming Chien

AU - Tsou, Hui Ming

AU - Hsiao, Yu Sheng

AU - Cheng, Yu Wei

AU - Liu, Che Chun

AU - Huang, Li Ying

AU - Peng, Xin Yao

AU - Liu, Ting Yu

AU - Yung, Ming Chi

AU - Hsu, Chuan Chih

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Y1 - 2019/9/1

N2 - In this study, a novel hemocompatible coating on stainless steel substrates was prepared by electrochemically copolymerizing 3,4-ethylenedioxythiophene (EDOT) with graphene oxide (GO), polystyrene sulfonate (PSS), or heparin (HEP) on SUS316L stainless steel, producing an anti-fouling (anti-protein adsorption and anti-platelet adhesion) surface to avoid the restenosis of blood vessels. The negative charges of GO, PSS, and HEP repel negatively charged proteins and platelets to achieve anti-fouling and anti-clotting. The results show that the anti-fouling capability of the poly(3,4-ethylenedioxythiophene) (PEDOT)/PSS coating is similar to that of the PEDOT/HEP coating. The anti-fouling capability of PEDOT/GO is higher than those of PEDOT/HEP and PEDOT/PSS. The reason for this is that GO exhibits negatively charged functional groups (COO-). The highest anti-fouling capability was found with the PEDOT/GO/HEP coating, indicating that electrochemical copolymerization of PEDOT with GO and HEP enhances the anti-fouling capability. Furthermore, the biocompatibility of the PEDOT coatings was tested with 3T3 cells for 1-5 days. The results show that all PEDOT composite coatings exhibited biocompatibility. The blood clotting time (APTT) of PEDOT/GO/HEP was prolonged to 225 s, much longer than the 40 s of pristine SUS316L stainless steel (the control), thus greatly improving the anti-blood-clotting capability of cardiovascular stents.

AB - In this study, a novel hemocompatible coating on stainless steel substrates was prepared by electrochemically copolymerizing 3,4-ethylenedioxythiophene (EDOT) with graphene oxide (GO), polystyrene sulfonate (PSS), or heparin (HEP) on SUS316L stainless steel, producing an anti-fouling (anti-protein adsorption and anti-platelet adhesion) surface to avoid the restenosis of blood vessels. The negative charges of GO, PSS, and HEP repel negatively charged proteins and platelets to achieve anti-fouling and anti-clotting. The results show that the anti-fouling capability of the poly(3,4-ethylenedioxythiophene) (PEDOT)/PSS coating is similar to that of the PEDOT/HEP coating. The anti-fouling capability of PEDOT/GO is higher than those of PEDOT/HEP and PEDOT/PSS. The reason for this is that GO exhibits negatively charged functional groups (COO-). The highest anti-fouling capability was found with the PEDOT/GO/HEP coating, indicating that electrochemical copolymerization of PEDOT with GO and HEP enhances the anti-fouling capability. Furthermore, the biocompatibility of the PEDOT coatings was tested with 3T3 cells for 1-5 days. The results show that all PEDOT composite coatings exhibited biocompatibility. The blood clotting time (APTT) of PEDOT/GO/HEP was prolonged to 225 s, much longer than the 40 s of pristine SUS316L stainless steel (the control), thus greatly improving the anti-blood-clotting capability of cardiovascular stents.

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KW - Electrochemical polymerization

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