Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats

Jiuan Miaw Liao, Hua Ting, Shin Da Lee, Chao Hsun Yang, Ying Ming Liou, Mei Lin Peng, Shih Jei Tsai, Chih Feng Lin, Tzer Bin Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of electroacupuncture (Ea) on circulatory dynamics were investigated in anesthetized rats. The arterial blood pressure (BP) and the heart rate (HR) in response to Ea stimulations at the Tsusanli point (St-36) and the Hoku point (Li-4) were tested by a low frequency Ea (2 Hz; LFEa) and a high frequency Ea (20 Hz; HFEa) with stimulation intensities 20 times the motor threshold. Neither the HR nor the BP was affected when the Tsusanli point was stimulated. Whereas, Ea stimulations at the Hoku point elicit chronotropic and pressor effects. The patterns of pressor responses caused by the LFEa were different from that of an HFEa, i.e., the LFEa elicited a tonic effect, while an HFEa had a phasic one. The HFEa-induced pressor and chronotropic effects were attenuated, while the LFEa induced effects were completely blocked by an intravenous infusion of an alpha-adrenergic blocker (moxisylyte 0.2 mg/min/kg, i.v., for 20 min). A co-infusion with alpha-and beta-adrenergic blockers (propanolol 0.2 mg/min/kg, i.v., for 20 min) completely blocked the HFEa-induced pressor and chronotropic effects. We concluded that Ea stimulations, at the Hoku acupoint, with appropriate stimulation parameters can increase and maintain BP. Furthermore, the LFEa stimulation activates sympathetic vasomotor tone, whereas the HFEa stimulation causes an additional potentiation on the sympathetic drive to the heart.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Volume124
Issue number1-2
DOIs
Publication statusPublished - Jan 30 2006
Externally publishedYes

Fingerprint

Electroacupuncture
Adrenergic alpha-Antagonists
Moxisylyte
Heart Rate
Blood Pressure
Acupuncture Points
Adrenergic beta-Antagonists
Intravenous Infusions
Propranolol
Arterial Pressure

Keywords

  • Blood pressure
  • Heart rate
  • Hoku
  • Rat
  • Stimulation
  • Tsusanli

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats. / Liao, Jiuan Miaw; Ting, Hua; Lee, Shin Da; Yang, Chao Hsun; Liou, Ying Ming; Peng, Mei Lin; Tsai, Shih Jei; Lin, Chih Feng; Lin, Tzer Bin.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 124, No. 1-2, 30.01.2006, p. 18-25.

Research output: Contribution to journalArticle

Liao, JM, Ting, H, Lee, SD, Yang, CH, Liou, YM, Peng, ML, Tsai, SJ, Lin, CF & Lin, TB 2006, 'Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats', Autonomic Neuroscience: Basic and Clinical, vol. 124, no. 1-2, pp. 18-25. https://doi.org/10.1016/j.autneu.2005.10.005
Liao, Jiuan Miaw ; Ting, Hua ; Lee, Shin Da ; Yang, Chao Hsun ; Liou, Ying Ming ; Peng, Mei Lin ; Tsai, Shih Jei ; Lin, Chih Feng ; Lin, Tzer Bin. / Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats. In: Autonomic Neuroscience: Basic and Clinical. 2006 ; Vol. 124, No. 1-2. pp. 18-25.
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AU - Liou, Ying Ming

AU - Peng, Mei Lin

AU - Tsai, Shih Jei

AU - Lin, Chih Feng

AU - Lin, Tzer Bin

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AB - The effects of electroacupuncture (Ea) on circulatory dynamics were investigated in anesthetized rats. The arterial blood pressure (BP) and the heart rate (HR) in response to Ea stimulations at the Tsusanli point (St-36) and the Hoku point (Li-4) were tested by a low frequency Ea (2 Hz; LFEa) and a high frequency Ea (20 Hz; HFEa) with stimulation intensities 20 times the motor threshold. Neither the HR nor the BP was affected when the Tsusanli point was stimulated. Whereas, Ea stimulations at the Hoku point elicit chronotropic and pressor effects. The patterns of pressor responses caused by the LFEa were different from that of an HFEa, i.e., the LFEa elicited a tonic effect, while an HFEa had a phasic one. The HFEa-induced pressor and chronotropic effects were attenuated, while the LFEa induced effects were completely blocked by an intravenous infusion of an alpha-adrenergic blocker (moxisylyte 0.2 mg/min/kg, i.v., for 20 min). A co-infusion with alpha-and beta-adrenergic blockers (propanolol 0.2 mg/min/kg, i.v., for 20 min) completely blocked the HFEa-induced pressor and chronotropic effects. We concluded that Ea stimulations, at the Hoku acupoint, with appropriate stimulation parameters can increase and maintain BP. Furthermore, the LFEa stimulation activates sympathetic vasomotor tone, whereas the HFEa stimulation causes an additional potentiation on the sympathetic drive to the heart.

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