Elbasvir/grazoprevir for hepatitis C virus genotype 1b East-Asian patients receiving hemodialysis

Chen-Hua Liu, Cheng-Yuan Peng, Yu-Jen Fang, Wei-Yu Kao, Sheng-Shun Yang, Cheng-Kuan Lin, Hsueh-Chou Lai, Wen-Pang Su, Sheng-Uei Fang, Chun-Chao Chang, Tung-Hung Su, Chun-Jen Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Data regarding the efficacy and tolerability of elbasvir/grazoprevir (EBR/GZR) for East-Asian hepatitis C virus genotype 1b (HCV GT1b) patients receiving hemodialysis were limited. We prospectively recruited 40 HCV GT1b hemodialysis patients who received EBR/GZR for 12 weeks at 6 academic centers in Taiwan. The efficacy endpoints were sustained virologic response 12 weeks off-therapy (SVR12) by intention-to-treat (ITT) modified ITT (mITT) analyses. Patients' baseline characteristics, early viral kinetics and HCV resistance-associated substitutions (RASs) at HCV non-structural 3 and 5 A (NS3 and NS5A) regions potentially affecting SVR12 were analyzed. The tolerability for EBR/GZR was also assessed. The SVR12 rates by ITT and mITT analyses were 95% (38 of 40 patients; 95% confidence interval (CI): 83.5-98.6%) and 100% (38 of 38 patients; 95% CI: 90.8-100%), respectively. Patients' baseline characteristics, on-treatment viral decline, and baseline HCV RASs did not affect SVR12. All patients tolerated treatment well. Among 5 patients who had serious adverse events (AEs) including one death due to on-treatment suicide and the other death due to off-therapy acute myocardial infarction, none of these events were judged related to EBR/GZR. The common AEs included upper respiratory tract infection (7.5%), fatigue (5.0%) and anorexia (5.0%). Nine (22.5%) and 8 (20.0%) patients had on-treatment hemoglobin levels of 9.0-10.0 g/dL and 7.0-9.0 g/dL. Three (7.5%) patients had on-treatment elevated alanine aminotransferase (ALT) quotient > 2.5, in whom one (2.5%) had EBR/GZR-induced late ALT elevation. No patients developed hyperbilirubinemia or hepatic decompensation. In conclusion, treatment with EBR/GZR is effective and well-tolerated for East-Asian HCV GT1b patients receiving hemodialysis.

Original languageEnglish
Pages (from-to)9180
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Jun 8 2020

Keywords

  • Amides/therapeutic use
  • Antiviral Agents/therapeutic use
  • Asian Continental Ancestry Group
  • Benzofurans/therapeutic use
  • Carbamates/therapeutic use
  • Cyclopropanes/therapeutic use
  • Drug Resistance, Viral/drug effects
  • Drug Therapy, Combination/methods
  • Female
  • Genotype
  • Hepacivirus/drug effects
  • Hepatitis C, Chronic/drug therapy
  • Humans
  • Imidazoles/therapeutic use
  • Male
  • Middle Aged
  • Quinoxalines/therapeutic use
  • Renal Dialysis/adverse effects
  • Sulfonamides/therapeutic use
  • Sustained Virologic Response

Fingerprint Dive into the research topics of 'Elbasvir/grazoprevir for hepatitis C virus genotype 1b East-Asian patients receiving hemodialysis'. Together they form a unique fingerprint.

Cite this