EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with lynch syndrome

Abram Bunya Kamiza, Wen Chang Wang, Jeng Fu You, Reiping Tang, Yen Ting Wang, Huei Tzu Chien, Chih Hsiung Lai, Li Ling Chiu, Tsai Ping Lo, Kuan Yi Hung, Chao Agnes Hsiung, Chih Ching Yeh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aim: Epidermal growth factor receptor (EGFR), mothers against decapentaplegic homolog 7 (SMAD7) and transforming growth factor betta (TGFB) are crucial for colorectal cancer (CRC) tumorigenesis. This study investigated whether polymorphisms in EGFR, SMAD7, and TGFB are associated with CRC risk in patients with Lynch syndrome. Materials and Methods: Genotyping was performed using Sequenom iPLEX MassArray. Association between genetic polymorphisms and CRC was assessed using a weighted Cox proportional hazard model. Results: Patients carrying the AA genotype of EGFR rs2227983 had a significantly higher CRC risk than those carrying the G allele (HR=2.55, 95% CI=1.25-5.17). The dominant model of SMAD7 rs12953717 (CT + TT genotypes) significantly increased CRC risk (HR=2.17, 95% CI=1.12-4.16) when compared to the wild-type CC genotype. Similarly, the GG genotype of TGFBR2 rs6785358 significantly increased the risk of CRC (HR=21.1, 95% CI=5.06-88.1) compared to the AA genotype. Conclusion: EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome.

Original languageEnglish
Pages (from-to)5983-5990
Number of pages8
JournalAnticancer Research
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Hereditary Nonpolyposis Colorectal Neoplasms
Epidermal Growth Factor Receptor
Colorectal Neoplasms
Genotype
Transforming Growth Factors
Smad Proteins
Genetic Polymorphisms
Proportional Hazards Models
Carcinogenesis
Alleles

Keywords

  • Colorectal cancer
  • CRC risk
  • EGFR
  • Lynch syndrome
  • Polymorphisms
  • SMAD7
  • TGFB

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with lynch syndrome. / Kamiza, Abram Bunya; Wang, Wen Chang; You, Jeng Fu; Tang, Reiping; Wang, Yen Ting; Chien, Huei Tzu; Lai, Chih Hsiung; Chiu, Li Ling; Lo, Tsai Ping; Hung, Kuan Yi; Hsiung, Chao Agnes; Yeh, Chih Ching.

In: Anticancer Research, Vol. 38, No. 10, 01.10.2018, p. 5983-5990.

Research output: Contribution to journalArticle

Kamiza, AB, Wang, WC, You, JF, Tang, R, Wang, YT, Chien, HT, Lai, CH, Chiu, LL, Lo, TP, Hung, KY, Hsiung, CA & Yeh, CC 2018, 'EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with lynch syndrome', Anticancer Research, vol. 38, no. 10, pp. 5983-5990. https://doi.org/10.21873/anticanres.12946
Kamiza, Abram Bunya ; Wang, Wen Chang ; You, Jeng Fu ; Tang, Reiping ; Wang, Yen Ting ; Chien, Huei Tzu ; Lai, Chih Hsiung ; Chiu, Li Ling ; Lo, Tsai Ping ; Hung, Kuan Yi ; Hsiung, Chao Agnes ; Yeh, Chih Ching. / EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with lynch syndrome. In: Anticancer Research. 2018 ; Vol. 38, No. 10. pp. 5983-5990.
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abstract = "Background/Aim: Epidermal growth factor receptor (EGFR), mothers against decapentaplegic homolog 7 (SMAD7) and transforming growth factor betta (TGFB) are crucial for colorectal cancer (CRC) tumorigenesis. This study investigated whether polymorphisms in EGFR, SMAD7, and TGFB are associated with CRC risk in patients with Lynch syndrome. Materials and Methods: Genotyping was performed using Sequenom iPLEX MassArray. Association between genetic polymorphisms and CRC was assessed using a weighted Cox proportional hazard model. Results: Patients carrying the AA genotype of EGFR rs2227983 had a significantly higher CRC risk than those carrying the G allele (HR=2.55, 95{\%} CI=1.25-5.17). The dominant model of SMAD7 rs12953717 (CT + TT genotypes) significantly increased CRC risk (HR=2.17, 95{\%} CI=1.12-4.16) when compared to the wild-type CC genotype. Similarly, the GG genotype of TGFBR2 rs6785358 significantly increased the risk of CRC (HR=21.1, 95{\%} CI=5.06-88.1) compared to the AA genotype. Conclusion: EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome.",
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AU - Kamiza, Abram Bunya

AU - Wang, Wen Chang

AU - You, Jeng Fu

AU - Tang, Reiping

AU - Wang, Yen Ting

AU - Chien, Huei Tzu

AU - Lai, Chih Hsiung

AU - Chiu, Li Ling

AU - Lo, Tsai Ping

AU - Hung, Kuan Yi

AU - Hsiung, Chao Agnes

AU - Yeh, Chih Ching

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AB - Background/Aim: Epidermal growth factor receptor (EGFR), mothers against decapentaplegic homolog 7 (SMAD7) and transforming growth factor betta (TGFB) are crucial for colorectal cancer (CRC) tumorigenesis. This study investigated whether polymorphisms in EGFR, SMAD7, and TGFB are associated with CRC risk in patients with Lynch syndrome. Materials and Methods: Genotyping was performed using Sequenom iPLEX MassArray. Association between genetic polymorphisms and CRC was assessed using a weighted Cox proportional hazard model. Results: Patients carrying the AA genotype of EGFR rs2227983 had a significantly higher CRC risk than those carrying the G allele (HR=2.55, 95% CI=1.25-5.17). The dominant model of SMAD7 rs12953717 (CT + TT genotypes) significantly increased CRC risk (HR=2.17, 95% CI=1.12-4.16) when compared to the wild-type CC genotype. Similarly, the GG genotype of TGFBR2 rs6785358 significantly increased the risk of CRC (HR=21.1, 95% CI=5.06-88.1) compared to the AA genotype. Conclusion: EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome.

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