EGFR mutations in malignant pleural effusion of non-small cell lung cancer: A case report

Ming Jer Huang, Ken Hong Lim, Chin Yuan Tzen, Han Shui Hsu, Yun Yen, Biing Shiun Huang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

EGFR mutations have been shown to correlate with the clinical responsiveness to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). The detection of EGFR mutations in non-small cell lung cancer (NSCLC) is important from the perspective of targeted anticancer therapy. We report the first case showing that the status of EGFR mutations can be successfully determined in malignant pleural effusion of NSCLC using polymerase chain reaction (PCR) technique, and correlated to the clinical responsiveness to gefitinib, an EGFR-TKI. This case demonstrated the importance of molecular cytology in the era of targeted therapy.

Original languageEnglish
Pages (from-to)413-415
Number of pages3
JournalLung Cancer
Volume49
Issue number3
DOIs
Publication statusPublished - Sep 1 2005
Externally publishedYes

Keywords

  • Epidermal growth factor receptor
  • Malignant pleural effusion
  • Mutations
  • Non-small cell lung cancer
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Oncology

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