EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1

Yung Sheng Chang, Wei Yu Chen, Juan Juan Yin, Heather Sheppard-Tillman, Jiaoti Huang, Yen Nien Liu

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Dysregulation of the EGFR signaling axis enhances bone metastases in many solid cancers. However, the relevant downstream effector signals in this axis are unclear. miR-1 was recently shown to function as a tumor suppressor in prostate cancer cells, where its expression correlated with reduced metastatic potential. In this study, we demonstrated a role for EGFR translocation in regulating transcription of miR-1-1, which directly targets expression of TWIST1. Consistent with these findings, we observed decreased miR-1 levels that correlated with enhanced expression of activated EGFR and TWIST1 in a cohort of human prostate cancer specimens and additional datasets. Our findings support a model in which nuclear EGFR acts as a transcriptional repressor to constrain the tumor-suppressive role of miR-1 and sustain oncogenic activation of TWIST1, thereby leading to accelerated bone metastasis.

Original languageEnglish
Pages (from-to)3077-3086
Number of pages10
JournalCancer Research
Volume75
Issue number15
DOIs
Publication statusPublished - Aug 1 2015

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Bone Neoplasms
Epidermal Growth Factor Receptor
Prostatic Neoplasms
Down-Regulation
Neoplasm Metastasis
Bone and Bones
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1. / Chang, Yung Sheng; Chen, Wei Yu; Yin, Juan Juan; Sheppard-Tillman, Heather; Huang, Jiaoti; Liu, Yen Nien.

In: Cancer Research, Vol. 75, No. 15, 01.08.2015, p. 3077-3086.

Research output: Contribution to journalArticle

Chang, Yung Sheng ; Chen, Wei Yu ; Yin, Juan Juan ; Sheppard-Tillman, Heather ; Huang, Jiaoti ; Liu, Yen Nien. / EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1. In: Cancer Research. 2015 ; Vol. 75, No. 15. pp. 3077-3086.
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