EGCG/gelatin-doxorubicin gold nanoparticles enhance therapeutic efficacy of doxorubicin for prostate cancer treatment

Li Chu Tsai, Hao Ying Hsieh, Kun Ying Lu, Sin Yu Wang, Fwu Long Mi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Aim: Development of epigallocatechin gallate (EGCG) and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) for fluorescence imaging and inhibition of prostate cancer cell growth. Materials & methods: AuNPs alternatively coated with EGCG and DOX-GLT conjugates were prepared by a layer-by-layer assembly method. The physicochemical properties of the AuNPs and the effect of Laminin 67R receptor-mediated endocytosis on the anticancer efficacy of the AuNPs were examined. Results: The AuNPs significantly inhibit the proliferation of PC-3 cancer cell and the enzyme-responsive intracellular release of DOX could be tracked by monitoring the recovery of the fluorescence signal of DOX. Conclusion: Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.

Original languageEnglish
Pages (from-to)9-30
Number of pages22
JournalNanomedicine
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • cellular uptake
  • doxorubicin
  • drug release
  • EGCG
  • gelatin
  • gold nanoparticles
  • Lam 67R
  • MMP-2
  • prostate cancer

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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