Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal

Hsueh Yun Lee, Grace Shiahuy Chen, Chien Shu Chen, Ji Wang Cherna

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18 Citations (Scopus)


The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number2
Publication statusPublished - Mar 2010
Externally publishedYes


ASJC Scopus subject areas

  • Organic Chemistry

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