Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal

Hsueh Yun Lee, Grace Shiahuy Chen, Chien Shu Chen, Ji Wang Cherna

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume47
Issue number2
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal'. Together they form a unique fingerprint.

  • Cite this