Efficacy of magnetic resonance diffusion tensor imaging and three-dimensional fiber tractography in the detection of clinical manifestations of central nervous system lupus

Shiou Ping Lee, Chien Sheng Wu, Li Chun Hsieh, Wing Keung Cheung, Ming Chung Chou

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease frequently associated with neuropsychiatric manifestations. No follow-up case report has characterized white matter alterations in patients with neuropsychiatric lupus erythematosus (NPSLE) before and after treatment. In this study, a 16-year-old NPSLE patient with severe neuropsychological symptoms was treated with steroid pulse therapy, and was scanned with conventional magnetic resonance (MR) and diffusion tensor imaging (DTI) at onset and 17. months after treatment. Conventional MR images showed diffuse brain atrophy and focal vasogenic edema in the putamen, but they did not reveal abnormalities in the corpus callosum. Region-of-interest analysis of DTI images showed that fractional anisotropy and fiber tracts increased significantly, while axial diffusivity, radial, and mean diffusivity decreased significantly in the corpus callosum after treatment. The results indicated that the vasogenic edema was present in the corpus callosum at onset and was significantly reduced after treatment. These changes were generally compatible with the patient's clinical manifestations. Hence, we concluded that MR-DTI and fiber tractography are helpful to reveal the relationship between white matter alterations and neurological dysfunctions in NPSLE patients.

Original languageEnglish
Pages (from-to)598-603
Number of pages6
JournalMagnetic Resonance Imaging
Volume32
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Central Nervous System Lupus Vasculitis
Diffusion tensor imaging
Diffusion Tensor Imaging
Neurology
Magnetic resonance
Magnetic Resonance Spectroscopy
Corpus Callosum
Fibers
Edema
Brain
Anisotropy
Therapeutics
Putamen
Systemic Lupus Erythematosus
Autoimmune Diseases
Atrophy
Steroids

Keywords

  • Corpus callosum
  • DTI
  • Fiber tractography
  • NPSLE

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering
  • Medicine(all)

Cite this

Efficacy of magnetic resonance diffusion tensor imaging and three-dimensional fiber tractography in the detection of clinical manifestations of central nervous system lupus. / Lee, Shiou Ping; Wu, Chien Sheng; Hsieh, Li Chun; Cheung, Wing Keung; Chou, Ming Chung.

In: Magnetic Resonance Imaging, Vol. 32, No. 5, 2014, p. 598-603.

Research output: Contribution to journalArticle

@article{7af23602515644e4a479a8cb7fd190e5,
title = "Efficacy of magnetic resonance diffusion tensor imaging and three-dimensional fiber tractography in the detection of clinical manifestations of central nervous system lupus",
abstract = "Systemic lupus erythematosus (SLE) is an autoimmune disease frequently associated with neuropsychiatric manifestations. No follow-up case report has characterized white matter alterations in patients with neuropsychiatric lupus erythematosus (NPSLE) before and after treatment. In this study, a 16-year-old NPSLE patient with severe neuropsychological symptoms was treated with steroid pulse therapy, and was scanned with conventional magnetic resonance (MR) and diffusion tensor imaging (DTI) at onset and 17. months after treatment. Conventional MR images showed diffuse brain atrophy and focal vasogenic edema in the putamen, but they did not reveal abnormalities in the corpus callosum. Region-of-interest analysis of DTI images showed that fractional anisotropy and fiber tracts increased significantly, while axial diffusivity, radial, and mean diffusivity decreased significantly in the corpus callosum after treatment. The results indicated that the vasogenic edema was present in the corpus callosum at onset and was significantly reduced after treatment. These changes were generally compatible with the patient's clinical manifestations. Hence, we concluded that MR-DTI and fiber tractography are helpful to reveal the relationship between white matter alterations and neurological dysfunctions in NPSLE patients.",
keywords = "Corpus callosum, DTI, Fiber tractography, NPSLE",
author = "Lee, {Shiou Ping} and Wu, {Chien Sheng} and Hsieh, {Li Chun} and Cheung, {Wing Keung} and Chou, {Ming Chung}",
year = "2014",
doi = "10.1016/j.mri.2014.02.005",
language = "English",
volume = "32",
pages = "598--603",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Efficacy of magnetic resonance diffusion tensor imaging and three-dimensional fiber tractography in the detection of clinical manifestations of central nervous system lupus

AU - Lee, Shiou Ping

AU - Wu, Chien Sheng

AU - Hsieh, Li Chun

AU - Cheung, Wing Keung

AU - Chou, Ming Chung

PY - 2014

Y1 - 2014

N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease frequently associated with neuropsychiatric manifestations. No follow-up case report has characterized white matter alterations in patients with neuropsychiatric lupus erythematosus (NPSLE) before and after treatment. In this study, a 16-year-old NPSLE patient with severe neuropsychological symptoms was treated with steroid pulse therapy, and was scanned with conventional magnetic resonance (MR) and diffusion tensor imaging (DTI) at onset and 17. months after treatment. Conventional MR images showed diffuse brain atrophy and focal vasogenic edema in the putamen, but they did not reveal abnormalities in the corpus callosum. Region-of-interest analysis of DTI images showed that fractional anisotropy and fiber tracts increased significantly, while axial diffusivity, radial, and mean diffusivity decreased significantly in the corpus callosum after treatment. The results indicated that the vasogenic edema was present in the corpus callosum at onset and was significantly reduced after treatment. These changes were generally compatible with the patient's clinical manifestations. Hence, we concluded that MR-DTI and fiber tractography are helpful to reveal the relationship between white matter alterations and neurological dysfunctions in NPSLE patients.

AB - Systemic lupus erythematosus (SLE) is an autoimmune disease frequently associated with neuropsychiatric manifestations. No follow-up case report has characterized white matter alterations in patients with neuropsychiatric lupus erythematosus (NPSLE) before and after treatment. In this study, a 16-year-old NPSLE patient with severe neuropsychological symptoms was treated with steroid pulse therapy, and was scanned with conventional magnetic resonance (MR) and diffusion tensor imaging (DTI) at onset and 17. months after treatment. Conventional MR images showed diffuse brain atrophy and focal vasogenic edema in the putamen, but they did not reveal abnormalities in the corpus callosum. Region-of-interest analysis of DTI images showed that fractional anisotropy and fiber tracts increased significantly, while axial diffusivity, radial, and mean diffusivity decreased significantly in the corpus callosum after treatment. The results indicated that the vasogenic edema was present in the corpus callosum at onset and was significantly reduced after treatment. These changes were generally compatible with the patient's clinical manifestations. Hence, we concluded that MR-DTI and fiber tractography are helpful to reveal the relationship between white matter alterations and neurological dysfunctions in NPSLE patients.

KW - Corpus callosum

KW - DTI

KW - Fiber tractography

KW - NPSLE

UR - http://www.scopus.com/inward/record.url?scp=84899058987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899058987&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2014.02.005

DO - 10.1016/j.mri.2014.02.005

M3 - Article

C2 - 24629511

AN - SCOPUS:84899058987

VL - 32

SP - 598

EP - 603

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 5

ER -