Efficacy and safety of Duhuo Jisheng Decoction add-on bisphosphonate medications in patients with osteoporosis: A meta-analysis of randomized controlled trials

Chung Yu Huang, Ciao Jhih Cheng, Wen Fei Chiou, Wei Chiao Chang, Yi No Kang, Mei Hsien Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Ethnopharmacological relevance: Duhuo Jisheng Decoction (DHJSD) is the most frequently prescribed herbal formula for the treatment of osteoporosis. However, efficacy and safety of DHJSD add-on bisphosphonate medications remain unclear. Aim of the study: The purpose of this study was to reveal efficacy and safety of DHJSD add-on bisphosphonate medications in patients with osteoporosis through a systematic review with meta-analysis of randomized controlled trials (RCTs). Methods: Five important databases were searched for RCTs on this topic, and two authors individually extracted information and data concerning study design, baseline characteristics, efficacy rate, bone mineral density (BMD), pain score, and adverse event. Meta-analysis was done mainly with risk ratio (RR) and standardized mean difference (SMD) for BMD and pain, using random-effects model; while Peto odds ratios (PORs) were used for pooling adverse event rates due to sparse data. Point estimate was reported with 95% confidence intervals (CIs). Results: Seventeen RCTs (n = 1526) met eligibility criteria, and were included in this synthesis. Pooled estimates demonstrated that as compared with no DHJSD, DHJSD-B led to significantly higher efficacy rates (RR = 1.25, 95%CI: 1.19–1.31; I2 = 0%), more lumbar BMD (SMD = 0.61, 95%CI: 0.25–0.96; I2 = 20%), lower pain score (SMD = −1.10, 95%CI: 1.40–0.79; I2 = 33%), and lower overall adverse event rates (POR = 0.40; 95%CI: 0.20–0.97; I2 = 27%). Conclusion: Adding DHJSD on bisphosphonate medications seems to be an effective and safe strategy in treating patients with osteoporosis.

Original languageEnglish
Article number114732
JournalJournal of Ethnopharmacology
Volume283
DOIs
Publication statusPublished - Jan 30 2022

Keywords

  • Bone loss
  • Chinese medicine
  • Duhuo jisheng decoction
  • Osteoporosis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Efficacy and safety of Duhuo Jisheng Decoction add-on bisphosphonate medications in patients with osteoporosis: A meta-analysis of randomized controlled trials'. Together they form a unique fingerprint.

Cite this