Abstract

In traditional Chinese medicine (TCM), both velvet antlers (VA) and VA blood can tonify qi, essence, and marrow, nourish the blood, and invigorate bones and tendons. In TCM, the combination of VA and VA blood is believed to have superior pharmacological effects. Scientific evidence supporting the traditional therapeutic preference for redder antler is needed. The effectiveness of the combination therapy of VA middle sections (VAMs) and VA blood (VAM-B) was first examined in promoting proliferation of mouse osteoblastic cells (MC3T3-E1). The anti-osteoporotic activity of VAM-B (ratio of VAM:VA blood = 1:0.2) was evaluated with ovariectomized (OVX) rats at a dose of 0.2 g/kg. In VAM-B-treated OVX rats, the body weight decreased 10.7%, and the strength of vertebrae and the femur respectively increased 18.1% and 15.4%, compared to the control. VAM-B treatment also recovered the estrogen-related loss of the right tibial trabecular bone microarchitecture. Alkaline phosphatase (ALP) significantly decreased, but estradiol did not significantly change in serum of VAM-B-treated OVX rats. We also provide an effective strategy to enhance the anti-osteoporotic activity of VAM. In conclusion, our results provide scientific evidence supporting the traditional therapeutic preference of redder antler and indicate that VAM-B is a potential therapeutic agent for managing osteoporosis.

Original languageEnglish
Pages (from-to)10574-10585
Number of pages12
JournalMolecules
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Antlers
bones
rats
blood
Rats
Bone
Blood
Bone and Bones
Chinese Traditional Medicine
medicine
Medicine
vertebrae
osteoporosis
Qi
estrogens
Therapeutics
femur
tendons
body weight
phosphatases

Keywords

  • Osteoporosis
  • Ovariectomized animal model
  • Velvet antler
  • Velvet antler blood
  • Velvet antler middle section

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Tseng, S. H., Sung, H. C., Chen, L. G., Lai, Y. J., Wang, K. T., Sung, C. H., & Wang, C. C. (2012). Effects of velvet antler with blood on bone in ovariectomized rats. Molecules, 17(9), 10574-10585. https://doi.org/10.3390/molecules170910574

Effects of velvet antler with blood on bone in ovariectomized rats. / Tseng, Sung Hui; Sung, Hsin Ching; Chen, Lih Geeng; Lai, Ying Jang; Wang, Kun Teng; Sung, Chun Hsien; Wang, Ching Chiung.

In: Molecules, Vol. 17, No. 9, 09.2012, p. 10574-10585.

Research output: Contribution to journalArticle

Tseng, SH, Sung, HC, Chen, LG, Lai, YJ, Wang, KT, Sung, CH & Wang, CC 2012, 'Effects of velvet antler with blood on bone in ovariectomized rats', Molecules, vol. 17, no. 9, pp. 10574-10585. https://doi.org/10.3390/molecules170910574
Tseng SH, Sung HC, Chen LG, Lai YJ, Wang KT, Sung CH et al. Effects of velvet antler with blood on bone in ovariectomized rats. Molecules. 2012 Sep;17(9):10574-10585. https://doi.org/10.3390/molecules170910574
Tseng, Sung Hui ; Sung, Hsin Ching ; Chen, Lih Geeng ; Lai, Ying Jang ; Wang, Kun Teng ; Sung, Chun Hsien ; Wang, Ching Chiung. / Effects of velvet antler with blood on bone in ovariectomized rats. In: Molecules. 2012 ; Vol. 17, No. 9. pp. 10574-10585.
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