Abstract

This study investigated the effects of ultrasound (US) at different frequencies on fracture healing over a three-week period in a rabbit fibular fracture model. Forty-five adult New Zealand White rabbits were divided into five groups: a control group and four groups treated with US frequencies of 0.5, 1.0, 1.5 and 2.0 MHz (0.5 W/cm 2, 200-μs burst, pulsed 1:4). After anesthesia, transverse osteotomy was performed on the fibula bone. This was followed by intravital staining and fluorescence microscopic examination of new bone formation and biomechanical tests of torsional stiffness at the osteotomy site. Results showed that total new bone formation and torsional stiffness of the fibula were greater in all US-treated groups than in the control group. No significant difference was found between any of the four US-treated groups. The US treatment also enhanced bone growth of the sham-treated contralateral fracture site. These results suggest that US treatment at 0.5, 1.0, 1.5 or 2.0 MHz can enhance fracture healing in a rabbit model. Furthermore, the effects of US on fracture healing at present parameters might not be confined locally.

Original languageEnglish
Pages (from-to)1635-1643
Number of pages9
JournalUltrasound in Medicine and Biology
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Fracture Healing
rabbits
healing
Osteotomy
Fibula
Rabbits
Osteogenesis
osteogenesis
Control Groups
Bone Development
bones
stiffness
Anesthesia
Fluorescence
Staining and Labeling
anesthesia
Bone and Bones
New Zealand
staining
Therapeutics

Keywords

  • Fractured bone healing
  • New bone growth
  • Torsional stiffness
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Effects of Ultrasound on Osteotomy Healing in a Rabbit Fracture Model. / Lai, Chien Hung; Chuang, Chiung Cheng; Kuan-Jung Li, Jimmy; Chen, Shih Ching; Hong-Shong Chang, Walter.

In: Ultrasound in Medicine and Biology, Vol. 37, No. 10, 10.2011, p. 1635-1643.

Research output: Contribution to journalArticle

Lai, Chien Hung ; Chuang, Chiung Cheng ; Kuan-Jung Li, Jimmy ; Chen, Shih Ching ; Hong-Shong Chang, Walter. / Effects of Ultrasound on Osteotomy Healing in a Rabbit Fracture Model. In: Ultrasound in Medicine and Biology. 2011 ; Vol. 37, No. 10. pp. 1635-1643.
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