Abstract

In traditional Chinese medicine (TCM), there are three Cheng-Chi-Tang decoctions (CCTDs) including: Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT) and Tiao-Wei-Chen-Chi-Tang (TWCCT), which are the frequently used purgative remedies to treat "internal heat"-induced symptoms like a bloated and painful abdomen, hard stools and fever, etc. Constituents in each formulation are Rheum palmatum L. (Polygonaceae), Magnolia officinalis Rehd. et Wils. (Magnoliaceae), Citrus aurantium L. (Rutaceae), Mirabilitum (mirabilite, crystals of sodium sulfate, Na2SO4) for TCCT; Rheum palmatum, Magnolia officinalis, Citrus aurantium for XCCT; and Rheum palmatum, Mirabilitum, Glycyrrhiza uralensis Fisch. (Leguminosae) for TWCCT. However, the underlying mechanisms for purging internal pathological heat are far from fully clarified, and few scientific investigations have been carried out to delineate the relationships between the anti-inflammatory effects and laxative potencies of these formulations. In this study, the anti-inflammatory effects of the three CCTDs on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E (PGE2) production in RAW 264.7 cells, carrageenan-induced paw edema in mice and the laxative effect in mice were explored. The results showed that TCCT inhibited LPS-induced NO and PGE2 production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells more effectively than did XCCT or TWCCT. Moreover, paw edema of carrageenan-treated mice was significantly attenuated in mice pretreated with 1 g/kg TCCT. TCCT also showed the strongest purgative activity among the three formulations. These findings indicate that TCCT has anti-inflammatory effects in addition to its traditionally known purgative activities. It may have potential to treat inflammatory disease conditions.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalJournal of Ethnopharmacology
Volume105
Issue number1-2
DOIs
Publication statusPublished - Apr 21 2006

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Cathartics
Rheum
Magnolia
Laxatives
Anti-Inflammatory Agents
Citrus
Carrageenan
Dinoprostone
Lipopolysaccharides
Magnoliaceae
Edema
Nitric Oxide
Polygonaceae
Glycyrrhiza uralensis
Hot Temperature
Rutaceae
Chinese Traditional Medicine
Nitric Oxide Synthase Type II
Prostaglandins E
Fabaceae

Keywords

  • Anti-inflammatory
  • Inflammatory mediators
  • Purgative
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of three purgative decoctions on inflammatory mediators. / Tseng, Sung Hui; Lee, Hsin Hsueh; Chen, Lih Geeng; Wu, Chih Hsiung; Wang, Ching Chiung.

In: Journal of Ethnopharmacology, Vol. 105, No. 1-2, 21.04.2006, p. 118-124.

Research output: Contribution to journalArticle

Tseng, Sung Hui ; Lee, Hsin Hsueh ; Chen, Lih Geeng ; Wu, Chih Hsiung ; Wang, Ching Chiung. / Effects of three purgative decoctions on inflammatory mediators. In: Journal of Ethnopharmacology. 2006 ; Vol. 105, No. 1-2. pp. 118-124.
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abstract = "In traditional Chinese medicine (TCM), there are three Cheng-Chi-Tang decoctions (CCTDs) including: Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT) and Tiao-Wei-Chen-Chi-Tang (TWCCT), which are the frequently used purgative remedies to treat {"}internal heat{"}-induced symptoms like a bloated and painful abdomen, hard stools and fever, etc. Constituents in each formulation are Rheum palmatum L. (Polygonaceae), Magnolia officinalis Rehd. et Wils. (Magnoliaceae), Citrus aurantium L. (Rutaceae), Mirabilitum (mirabilite, crystals of sodium sulfate, Na2SO4) for TCCT; Rheum palmatum, Magnolia officinalis, Citrus aurantium for XCCT; and Rheum palmatum, Mirabilitum, Glycyrrhiza uralensis Fisch. (Leguminosae) for TWCCT. However, the underlying mechanisms for purging internal pathological heat are far from fully clarified, and few scientific investigations have been carried out to delineate the relationships between the anti-inflammatory effects and laxative potencies of these formulations. In this study, the anti-inflammatory effects of the three CCTDs on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E (PGE2) production in RAW 264.7 cells, carrageenan-induced paw edema in mice and the laxative effect in mice were explored. The results showed that TCCT inhibited LPS-induced NO and PGE2 production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells more effectively than did XCCT or TWCCT. Moreover, paw edema of carrageenan-treated mice was significantly attenuated in mice pretreated with 1 g/kg TCCT. TCCT also showed the strongest purgative activity among the three formulations. These findings indicate that TCCT has anti-inflammatory effects in addition to its traditionally known purgative activities. It may have potential to treat inflammatory disease conditions.",
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AU - Lee, Hsin Hsueh

AU - Chen, Lih Geeng

AU - Wu, Chih Hsiung

AU - Wang, Ching Chiung

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AB - In traditional Chinese medicine (TCM), there are three Cheng-Chi-Tang decoctions (CCTDs) including: Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT) and Tiao-Wei-Chen-Chi-Tang (TWCCT), which are the frequently used purgative remedies to treat "internal heat"-induced symptoms like a bloated and painful abdomen, hard stools and fever, etc. Constituents in each formulation are Rheum palmatum L. (Polygonaceae), Magnolia officinalis Rehd. et Wils. (Magnoliaceae), Citrus aurantium L. (Rutaceae), Mirabilitum (mirabilite, crystals of sodium sulfate, Na2SO4) for TCCT; Rheum palmatum, Magnolia officinalis, Citrus aurantium for XCCT; and Rheum palmatum, Mirabilitum, Glycyrrhiza uralensis Fisch. (Leguminosae) for TWCCT. However, the underlying mechanisms for purging internal pathological heat are far from fully clarified, and few scientific investigations have been carried out to delineate the relationships between the anti-inflammatory effects and laxative potencies of these formulations. In this study, the anti-inflammatory effects of the three CCTDs on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E (PGE2) production in RAW 264.7 cells, carrageenan-induced paw edema in mice and the laxative effect in mice were explored. The results showed that TCCT inhibited LPS-induced NO and PGE2 production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells more effectively than did XCCT or TWCCT. Moreover, paw edema of carrageenan-treated mice was significantly attenuated in mice pretreated with 1 g/kg TCCT. TCCT also showed the strongest purgative activity among the three formulations. These findings indicate that TCCT has anti-inflammatory effects in addition to its traditionally known purgative activities. It may have potential to treat inflammatory disease conditions.

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