Effects of the nanostructure and nanoporosity on bioactive nanohydroxyapatite/reconstituted collagen by electrodeposition

Keng Liang Ou, Jeffery Wu, Wen-FuThomas Lai, Charng Bin Yang, Wen Chang Lo, Li Hsuan Chiu, John Bowley

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Hydroxyapatite (HA)/collagen composites were reported to induce bony growth. Various methods for preparing HA-based composites have been investigated as potential biomaterials for bone substitutes. However, no method can generate a thick nanoporous HA. A novel bone regenerative nanocomposite consisting of nanohydroxyapatite (HA), nano-amorphous calcium phosphate (ACP) and reconstituted collagen by electrodeposition was designed in this research. Specimens with and without nanoporosity were evaluated using electrochemical measurements, material analyses, and cell-material interactions. The results showed that reconstituted collagen/nano-(HA and ACP) illustrated a multinanoporous structure and enhanced biocompatibility. Nanocomposite was comprised to nano-(HA and ACP) and reconstituted collagen. The core cell structure was formed during electrodeposition. Nanoporosity and nanostructure were observed as formation of nanocomposite. The nano-(HA and ACP) phases were essentially composed of a nanoporous and nanostructural biocomposite. Reconstituted collagen incorporation with the nanoporous and nanostructural biocomposite significantly facilitated the osteogenic differentiation of mesenchymal stem cells. Reconstituted collagen was covered with nano-(HA and ACP), profoundly impacting the enhancement of biocompatibility on application of implant and tissue engineering. The bioactive nano-HA/reconstituted collagen-induced osteogenic differentiation of mesenchymal stem cells enables to enhance bone growth/ repair and osseointegration.

Original languageEnglish
Pages (from-to)906-912
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume92
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

Fingerprint

Durapatite
Hydroxyapatite
Collagen
Electrodeposition
Nanostructures
Calcium phosphate
Nanocomposites
Stem cells
Biocompatibility
Bone
Bone Substitutes
Composite materials
Biocompatible Materials
Tissue engineering
Repair
Biomaterials
amorphous calcium phosphate

Keywords

  • Electrodeposition
  • Mesenchymal stem cell
  • Nano-amorphous calcium phosphate
  • Nano-hydroxyapatite
  • Reconstituted collagen

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

Cite this

Effects of the nanostructure and nanoporosity on bioactive nanohydroxyapatite/reconstituted collagen by electrodeposition. / Ou, Keng Liang; Wu, Jeffery; Lai, Wen-FuThomas; Yang, Charng Bin; Lo, Wen Chang; Chiu, Li Hsuan; Bowley, John.

In: Journal of Biomedical Materials Research - Part A, Vol. 92, No. 3, 01.03.2010, p. 906-912.

Research output: Contribution to journalArticle

Ou, Keng Liang ; Wu, Jeffery ; Lai, Wen-FuThomas ; Yang, Charng Bin ; Lo, Wen Chang ; Chiu, Li Hsuan ; Bowley, John. / Effects of the nanostructure and nanoporosity on bioactive nanohydroxyapatite/reconstituted collagen by electrodeposition. In: Journal of Biomedical Materials Research - Part A. 2010 ; Vol. 92, No. 3. pp. 906-912.
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