Effects of testosterone on the metabolism of arachidonic acid by aortas and platelets in rats

Wen Chang Chang, Junko Nakao, Hsin Hsiung Tai, Sei itsu Murota

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of testosterone on the prostacyclin production by aortas and the biosynthesis of thromboxane in platelets of male rats in vivo were investigated.Testosterone significantly inhibits prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. The results provide a plausible explanation for the thrombogenic effect of testosterone in rats.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalProstaglandins, Leukotrienes and Medicine
Volume9
Issue number5
DOIs
Publication statusPublished - 1982
Externally publishedYes

Fingerprint

Platelets
Arachidonic Acid
Metabolism
Aorta
Testosterone
Rats
Blood Platelets
Thromboxanes
Biosynthesis
Epoprostenol

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Effects of testosterone on the metabolism of arachidonic acid by aortas and platelets in rats. / Chang, Wen Chang; Nakao, Junko; Tai, Hsin Hsiung; Murota, Sei itsu.

In: Prostaglandins, Leukotrienes and Medicine, Vol. 9, No. 5, 1982, p. 495-501.

Research output: Contribution to journalArticle

@article{5d4a3e31c6444ddf8c20c42814b1fb8e,
title = "Effects of testosterone on the metabolism of arachidonic acid by aortas and platelets in rats",
abstract = "The effects of testosterone on the prostacyclin production by aortas and the biosynthesis of thromboxane in platelets of male rats in vivo were investigated.Testosterone significantly inhibits prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. The results provide a plausible explanation for the thrombogenic effect of testosterone in rats.",
author = "Chang, {Wen Chang} and Junko Nakao and Tai, {Hsin Hsiung} and Murota, {Sei itsu}",
year = "1982",
doi = "10.1016/0262-1746(82)90030-0",
language = "English",
volume = "9",
pages = "495--501",
journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",
issn = "0952-3278",
publisher = "Churchill Livingstone",
number = "5",

}

TY - JOUR

T1 - Effects of testosterone on the metabolism of arachidonic acid by aortas and platelets in rats

AU - Chang, Wen Chang

AU - Nakao, Junko

AU - Tai, Hsin Hsiung

AU - Murota, Sei itsu

PY - 1982

Y1 - 1982

N2 - The effects of testosterone on the prostacyclin production by aortas and the biosynthesis of thromboxane in platelets of male rats in vivo were investigated.Testosterone significantly inhibits prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. The results provide a plausible explanation for the thrombogenic effect of testosterone in rats.

AB - The effects of testosterone on the prostacyclin production by aortas and the biosynthesis of thromboxane in platelets of male rats in vivo were investigated.Testosterone significantly inhibits prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. The results provide a plausible explanation for the thrombogenic effect of testosterone in rats.

UR - http://www.scopus.com/inward/record.url?scp=0020400512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020400512&partnerID=8YFLogxK

U2 - 10.1016/0262-1746(82)90030-0

DO - 10.1016/0262-1746(82)90030-0

M3 - Article

VL - 9

SP - 495

EP - 501

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

SN - 0952-3278

IS - 5

ER -