Effects of testosterone on the metabolism of arachidonic acid by aortas and platelets in rats

Wen Chang Chang, Junko Nakao, Hsin Hsiung Tai, Sei itsu Murota

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of testosterone on the prostacyclin production by aortas and the biosynthesis of thromboxane in platelets of male rats in vivo were investigated.Testosterone significantly inhibits prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. The results provide a plausible explanation for the thrombogenic effect of testosterone in rats.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalProstaglandins, Leukotrienes and Medicine
Volume9
Issue number5
DOIs
Publication statusPublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

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