Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats

K. W. Chang, M. C. Lin, S. Y. Lee, H. Y. Chen, C. C. Chen, Y. K. Fu

Research output: Contribution to journalArticle

Abstract

Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ 123I]ADAM ([ 123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ 123I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ 123I]ADAM was not toxic in an animal pregnancy model.

Original languageEnglish
Pages (from-to)2646-2651
Number of pages6
JournalApplied Radiation and Isotopes
Volume70
Issue number11
DOIs
Publication statusPublished - Nov 1 2012
Externally publishedYes

Fingerprint

serotonin
transporter
pregnancy
rats
fertility
mortality
abnormalities
toxicity
animals
disorders

Keywords

  • ADAM
  • Animal pregnancy model
  • Depression
  • Toxicity

ASJC Scopus subject areas

  • Radiation

Cite this

Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats. / Chang, K. W.; Lin, M. C.; Lee, S. Y.; Chen, H. Y.; Chen, C. C.; Fu, Y. K.

In: Applied Radiation and Isotopes, Vol. 70, No. 11, 01.11.2012, p. 2646-2651.

Research output: Contribution to journalArticle

Chang, K. W. ; Lin, M. C. ; Lee, S. Y. ; Chen, H. Y. ; Chen, C. C. ; Fu, Y. K. / Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats. In: Applied Radiation and Isotopes. 2012 ; Vol. 70, No. 11. pp. 2646-2651.
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