Effects of sumatriptan nasal spray (Imigran) on human nasal mucosa

L. H. Cheng, P. C. Wu, Y. Y. Lin, Y. H. Chu, H. W. Wang

Research output: Contribution to journalArticle

Abstract

Objectives: Sumatriptan (Imigran) is a potent and highly selective 5-HT1 receptor agonist often used in treating acute migraine. Intranasal sumatriptan is well absorbed and is generally effective in relieving headache. However, the effects of Imigran on human nasal mucosa have rarely been well explored, to verify the effect of Imigran, which act on human nasal mucosa directly in vitro. Design and participants: We examined the effectiveness of Imigran on human nasal mucosa by testing: (i) effect on human nasal mucosa resting tension; (ii) effect on contraction caused by 10-6 mol/L methoxamine as a sympathetic mimetic; and (iii) effect of the drugs on electrically induced on human nasal mucosa contractions. Results: The results indicated that addition of methoxamine to the incubation medium caused the nasal mucosa to contract in a dose-dependent manner. Addition of Imigran at doses of 10-4 mol/L elicited a significant relaxation response to 10-6 mol/L methoxamine-induced contraction. Imigran could not inhibit electrical field stimulation-induced spike contraction. It also had a minimal effect on the basal tension of nasal mucosa as the concentration increased. Conclusions: The study indicated that high concentrations of Imigran had a significant spasmolytic effect by antagonising α-adreoceptors and nasal obstruction could not be released in the patient combined with acute migraine and stuffy nose by concomitant α-adrenergic agonist nasal spray plus Imigran nasal spray.

Original languageEnglish
JournalClinical Otolaryngology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Sumatriptan
Nasal Sprays
Nasal Mucosa
Methoxamine
Migraine Disorders
Serotonin 5-HT1 Receptors
Serotonin 5-HT1 Receptor Agonists
Parasympatholytics
Adrenergic Agonists
Nasal Obstruction
Nose
Electric Stimulation
Headache

Keywords

  • Human nasal mucosa
  • Imigran
  • Sympathetic function

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effects of sumatriptan nasal spray (Imigran) on human nasal mucosa. / Cheng, L. H.; Wu, P. C.; Lin, Y. Y.; Chu, Y. H.; Wang, H. W.

In: Clinical Otolaryngology, 01.01.2018.

Research output: Contribution to journalArticle

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